| pubmed-article:15028767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0072482 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0132298 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C1522949 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15028767 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15028767 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15028767 | pubmed:dateCreated | 2004-3-18 | lld:pubmed |
| pubmed-article:15028767 | pubmed:abstractText | Nerve growth factor (NGF) functions as a ligand for two receptors, the TrkA tyrosine kinase receptor and the p75 neurotrophin receptor (p75NTR). The Ig-like domains of Trk receptors and the cysteine-rich repeats of p75NTR are involved in binding to the neurotrophins. Recently, a closely related gene to p75NTR called neurotrophin receptor homolog-2 (NRH2) was identified; however, the function of NRH2 and its relevance to neurotrophin signaling are unclear. NRH2 contains a similar transmembrane and intracellular domain as p75NTR but lacks the characteristic cysteine-rich repeats in the extracellular domain. Here we show that NRH2 is expressed in several neuronal populations that also express p75NTR and Trk receptors. NRH2 does not bind to NGF; however, coimmunoprecipitation experiments demonstrate that NRH2 is capable of interacting with TrkA receptors. Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties. | lld:pubmed |
| pubmed-article:15028767 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028767 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15028767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028767 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15028767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15028767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15028767 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15028767 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:15028767 | pubmed:author | pubmed-author:ChaoMoses VMV | lld:pubmed |
| pubmed-article:15028767 | pubmed:author | pubmed-author:HempsteadBarb... | lld:pubmed |
| pubmed-article:15028767 | pubmed:author | pubmed-author:PerezPilarP | lld:pubmed |
| pubmed-article:15028767 | pubmed:author | pubmed-author:LeeRameeR | lld:pubmed |
| pubmed-article:15028767 | pubmed:author | pubmed-author:MurraySimon... | lld:pubmed |
| pubmed-article:15028767 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15028767 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:15028767 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15028767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15028767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15028767 | pubmed:pagination | 2742-9 | lld:pubmed |
| pubmed-article:15028767 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15028767 | pubmed:meshHeading | pubmed-meshheading:15028767... | lld:pubmed |
| pubmed-article:15028767 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15028767 | pubmed:articleTitle | A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor. | lld:pubmed |
| pubmed-article:15028767 | pubmed:affiliation | Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. s.murray@hfi.unimelb.edu.au | lld:pubmed |
| pubmed-article:15028767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15028767 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15028767 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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