| pubmed-article:15028707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C0038423 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C1551359 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:15028707 | lifeskim:mentions | umls-concept:C1566952 | lld:lifeskim |
| pubmed-article:15028707 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15028707 | pubmed:dateCreated | 2004-3-18 | lld:pubmed |
| pubmed-article:15028707 | pubmed:abstractText | In the model of the A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) regulatory cascade in Streptomyces griseus, A-factor binds ArpA, the A-factor receptor protein, that has bound to the adpA promoter and dissociates it from the DNA, thus inducing the transcription of adpA. AdpA switches on the transcription of a number of genes required for secondary metabolism and morphological differentiation, forming an AdpA regulon. Consistent with this model, arpA null mutants produced streptomycin and a yellow pigment in larger amounts and formed aerial hyphae from an earlier growth stage than the wild-type strain. On the other hand, mutant MK2, expressing a mutant ArpA (Trp119Ala), neither produced secondary metabolites nor formed aerial hyphae, because this A-factor-insensitive mutant ArpA always bound to and repressed the adpA promoter due to the amino acid replacement of Trp-119 with Ala. Introduction of adpA under the control of a foreign promoter into mutant MK2 restored all of the phenotypes that we could observe, which suggests that the only significant target of ArpA is adpA. In contrast to other gamma-butyrolactone regulatory systems, disruption of arpA had no effect on A-factor production, indicating that ArpA does not regulate A-factor biosynthesis. Instead, A-factor production was found to be repressed by AdpA in a two-step regulatory feedback loop. | lld:pubmed |
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| pubmed-article:15028707 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15028707 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028707 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15028707 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15028707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15028707 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15028707 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:15028707 | pubmed:author | pubmed-author:KatoJun-yaJY | lld:pubmed |
| pubmed-article:15028707 | pubmed:author | pubmed-author:OhnishiYasuoY | lld:pubmed |
| pubmed-article:15028707 | pubmed:author | pubmed-author:HorinouchiSue... | lld:pubmed |
| pubmed-article:15028707 | pubmed:author | pubmed-author:MiyahisaIkuoI | lld:pubmed |
| pubmed-article:15028707 | pubmed:author | pubmed-author:MashikoMariM | lld:pubmed |
| pubmed-article:15028707 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15028707 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:15028707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15028707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15028707 | pubmed:pagination | 2206-11 | lld:pubmed |
| pubmed-article:15028707 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15028707 | pubmed:meshHeading | pubmed-meshheading:15028707... | lld:pubmed |
| pubmed-article:15028707 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15028707 | pubmed:articleTitle | A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus. | lld:pubmed |
| pubmed-article:15028707 | pubmed:affiliation | Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. | lld:pubmed |
| pubmed-article:15028707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15028707 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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