| pubmed-article:15028619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15028619 | lifeskim:mentions | umls-concept:C1425233 | lld:lifeskim |
| pubmed-article:15028619 | lifeskim:mentions | umls-concept:C1565114 | lld:lifeskim |
| pubmed-article:15028619 | lifeskim:mentions | umls-concept:C2817684 | lld:lifeskim |
| pubmed-article:15028619 | pubmed:dateCreated | 2004-3-18 | lld:pubmed |
| pubmed-article:15028619 | pubmed:abstractText | Active cell death, also known as apoptosis, has been implicated in the pathophysiology of diseases such as cancer, heart failure and neurodegenerative disorders. We report the anti-apoptotic function of IRAS, which was previously shown to bind imidazoline ligands. The amino acid sequence of human IRAS (hIRAS) is unrelated to known proteins, except for rat IRAS and a mouse homologue named nischarin, which binds the alpha5 integrin subunit of the fibronectin receptor. When stably transfected into PC12 cells, hIRAS localizes to the cytosol as a 167 kDa immunoreactive protein. Clonal PC12 cell lines expressing hIRAS displayed normal serum growth responses. However, hIRAS expression led to prolonged cell survival against known apoptotic stimuli: serum starvation or thapsigargin or staurosporine treatments. The apoptotic population of hIRAS-expressing cells was significantly reduced, and this protection was achieved by a decrease in caspase-3 activity, phosphatidylserine translocation, and nuclear fragmentation. Similar protective effect was obtained in COS7 cells transiently transfected with hIRAS. A partial activation of the PI3 kinase pathway is possibly implicated in the anti-apoptotic effect of IRAS. Thus, IRAS appears to represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival. | lld:pubmed |
| pubmed-article:15028619 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15028619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15028619 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15028619 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:DontenwillMon... | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:TakedaKenK | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:PiletzJohn... | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:ChenMichaelM | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:GreneyHuguesH | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:DupuyLaurence... | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:BaldwinJamesJ | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:PascalGeraldi... | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:RondePhilippe... | lld:pubmed |
| pubmed-article:15028619 | pubmed:author | pubmed-author:BousquetdPasc... | lld:pubmed |
| pubmed-article:15028619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15028619 | pubmed:volume | 1009 | lld:pubmed |
| pubmed-article:15028619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15028619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15028619 | pubmed:pagination | 400-12 | lld:pubmed |
| pubmed-article:15028619 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15028619 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:15028619 | pubmed:articleTitle | IRAS is an anti-apoptotic protein. | lld:pubmed |
| pubmed-article:15028619 | pubmed:affiliation | Pharmacologie et Physicochimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Illkirch, France. mdontenwill@aspirine.u-strasbg.fr | lld:pubmed |
| pubmed-article:15028619 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15028619 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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