| pubmed-article:15028021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C0279751 | lld:lifeskim |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C1522609 | lld:lifeskim |
| pubmed-article:15028021 | lifeskim:mentions | umls-concept:C1554112 | lld:lifeskim |
| pubmed-article:15028021 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15028021 | pubmed:dateCreated | 2004-3-18 | lld:pubmed |
| pubmed-article:15028021 | pubmed:abstractText | The purpose of the present study was to investigate the level of apoptosis and expressions of p53, mdm2 and bcl-2 proteins in salivary gland adenoid cystic carcinoma (ACC) to determine potential relationships among apoptosis, apoptosis-associated proteins and clinical cumulative survival. Thirty-nine formalin-fixed, paraffin-embedded cases, cribriform (17), tubular (13) and solid (9), were studied by immunohistochemistry. Apoptosis detection and analysis were determined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL). There was an inverse significance between the apoptotic index (AI) and bcl-2 expression (P = 0.018), whereas no correlation was found between the AI and either p53 or mdm2 expression (P = 0.416 and P = 0.456). Co-expression of p53 and mdm2 was found in 22 cases (P = 0.037). Patients with p53-positive tumors had a worse prognosis than those with p53-negative tumors (P = 0.014). Patients with a high AI had a better cumulative survival than patients with a low AI (P = 0.038). The present study suggests that p53 expression and AI can be useful as prognostic values; bcl-2 protein plays a role in the down-regulation of apoptosis and is also potentially useful as a prognostic parameter in salivary gland ACC. | lld:pubmed |
| pubmed-article:15028021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15028021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15028021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15028021 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15028021 | pubmed:issn | 1320-5463 | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:SUNW HWH | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:SakamotoKeiK | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:TakagiMinoruM | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:OkadaNorihiko... | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:TangXiaofeiX | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:YinHongfangH | lld:pubmed |
| pubmed-article:15028021 | pubmed:author | pubmed-author:EsguerraRenel... | lld:pubmed |
| pubmed-article:15028021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15028021 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:15028021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15028021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15028021 | pubmed:pagination | 217-23 | lld:pubmed |
| pubmed-article:15028021 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
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| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:meshHeading | pubmed-meshheading:15028021... | lld:pubmed |
| pubmed-article:15028021 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15028021 | pubmed:articleTitle | Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma. | lld:pubmed |
| pubmed-article:15028021 | pubmed:affiliation | Molecular Pathology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. linjia73@yahoo.co.jp | lld:pubmed |
| pubmed-article:15028021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15028021 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15028021 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
