Rate of enolate formation is not very sensitive to the hydrogen bonding ability of donors to carboxyl oxygen lone pair acceptors; a ramification of the principle of non-perfect synchronization for general-base-catalyzed enolate formation.

Source:http://linkedlifedata.com/resource/pubmed/id/15025476

J. Am. Chem. Soc. 2004 Mar 24 126 11 3488-95

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15025476