| pubmed-article:15024044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15024044 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:15024044 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15024044 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15024044 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15024044 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15024044 | pubmed:dateCreated | 2004-3-16 | lld:pubmed |
| pubmed-article:15024044 | pubmed:abstractText | Understanding the pathways that signal T cell tolerance versus activation is key to regulating immunity. Previous studies have linked CD28 and protein kinase C-theta (PKCtheta) as a potential signaling pathway that influences T cell activation. Therefore, we have compared the responses of T cells deficient for CD28 and PKCtheta in vivo and in vitro. Here, we demonstrate that the absence of PKCtheta leads to the induction of T cell anergy, with a phenotype that is comparable to the absence of CD28. Further experiments examined whether PKCtheta triggered other CD28-dependent responses. Our data show that CD4 T cell-B cell cooperation is dependent on CD28 but not PKCtheta, whereas CD28 costimulatory signals that augment proliferation can be uncoupled from signals that regulate anergy. Therefore, PKCtheta relays a defined subset of CD28 signals during T cell activation and is critical for the induction of activation versus tolerance in vivo. | lld:pubmed |
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| pubmed-article:15024044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15024044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15024044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15024044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15024044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15024044 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15024044 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:OdermattBernh... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:LittmanDan... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:ElfordAlisha... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:OhashiPamela... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:JonesRussell... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:DeenickElissa... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:GronskiMatthe... | lld:pubmed |
| pubmed-article:15024044 | pubmed:author | pubmed-author:Berg-BrownNan... | lld:pubmed |
| pubmed-article:15024044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15024044 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15024044 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:15024044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15024044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15024044 | pubmed:pagination | 743-52 | lld:pubmed |
| pubmed-article:15024044 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15024044 | pubmed:meshHeading | pubmed-meshheading:15024044... | lld:pubmed |
| pubmed-article:15024044 | pubmed:meshHeading | pubmed-meshheading:15024044... | lld:pubmed |
