| pubmed-article:15016819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:15016819 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:15016819 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:15016819 | pubmed:dateCreated | 2004-5-10 | lld:pubmed |
| pubmed-article:15016819 | pubmed:abstractText | Ca2+-induced Ca2+ release (CICR) is a well characterized activity in skeletal and cardiac muscles mediated by the ryanodine receptors. The present study demonstrates CICR in the non-excitable parotid acinar cells, which resembles the mechanism described in cardiac myocytes. Partial depletion of internal Ca2+ stores leads to a minimal activation of Ca2+ influx. Ca2+ influx through this pathway results in an explosive mobilization of Ca2+ from the majority of the stores by CICR. Thus, stimulation of parotid acinar cells in Ca2+ -free medium with 0.5 microm carbachol releases approximately 5% of the Ca2+ mobilizable by 1 mm carbachol. Addition of external Ca2+ induced the same Ca2+ release observed in maximally stimulated cells. Similar results were obtained by a short treatment with 2.5-10 microm cyclopiazonic acid, an inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase pump. The Ca2+ release induced by the addition of external Ca2+ was largely independent of IP(3)Rs because it was reduced by only approximately 30% by the inhibition of the inositol 1,4,5-trisphosphate receptors with caffeine or heparin. Measurements of Ca2+ -activated outward current and [Ca2+](i) suggested that most CICR triggered by Ca2+ influx occurred away from the plasma membrane. Measurement of the response to several concentrations of cyclopiazonic acid revealed that Ca2+ influx that regulates CICR is associated with a selective portion of the internal Ca2+ pool. The minimal activation of Ca2+ influx by partial store depletion was confirmed by the measurement of Mn2+ influx. Inhibition of Ca2+ influx with SKF96365 or 2-aminoethoxydiphenyl borate prevented activation of CICR observed on addition of external Ca2+. These findings provide evidence for activation of CICR by Ca2+ influx in non-excitable cells, demonstrate a previously unrecognized role for Ca2+ influx in triggering CICR, and indicate that CICR in non-excitable cells resembles CICR in cardiac myocytes with the exception that in cardiac cells Ca2+ influx is mediated by voltage-regulated Ca2+ channels whereas in non-excitable cells Ca2+ influx is mediated by store-operated channels. | lld:pubmed |
| pubmed-article:15016819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15016819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15016819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15016819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15016819 | pubmed:month | May | lld:pubmed |
| pubmed-article:15016819 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15016819 | pubmed:author | pubmed-author:OcaFF | lld:pubmed |
| pubmed-article:15016819 | pubmed:author | pubmed-author:DeebZ EZE | lld:pubmed |
| pubmed-article:15016819 | pubmed:author | pubmed-author:HnatRR | lld:pubmed |
| pubmed-article:15016819 | pubmed:author | pubmed-author:MuallemShmuel... | lld:pubmed |
| pubmed-article:15016819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15016819 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:15016819 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15016819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15016819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15016819 | pubmed:pagination | 21511-9 | lld:pubmed |
| pubmed-article:15016819 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:meshHeading | pubmed-meshheading:15016819... | lld:pubmed |
| pubmed-article:15016819 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15016819 | pubmed:articleTitle | Subpopulation of store-operated Ca2+ channels regulate Ca2+-induced Ca2+ release in non-excitable cells. | lld:pubmed |
| pubmed-article:15016819 | pubmed:affiliation | Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9040, USA. | lld:pubmed |
| pubmed-article:15016819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15016819 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15016819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15016819 | lld:pubmed |
