| pubmed-article:15014079 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15014079 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15014079 | lifeskim:mentions | umls-concept:C0019796 | lld:lifeskim |
| pubmed-article:15014079 | lifeskim:mentions | umls-concept:C1155661 | lld:lifeskim |
| pubmed-article:15014079 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15014079 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:15014079 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:15014079 | pubmed:dateCreated | 2004-5-10 | lld:pubmed |
| pubmed-article:15014079 | pubmed:abstractText | Defects in human DNA mismatch repair predispose to cancer, but many components of the pathway have not been identified. We report here the identification and characterization of a novel component required for mismatch repair in human cells. A 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in repair of mismatched heteroduplexes. The complementing activity was identified as HMGB1 (the high mobility group box 1 protein), a non-histone chromatin protein that facilitates protein-protein interactions and recognizes DNA damage. Evidence is also presented that HMGB1 physically interacts with MutSalpha and is required at a step prior to the excision of mispaired nucleotide in mismatch repair. | lld:pubmed |
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| pubmed-article:15014079 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15014079 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15014079 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15014079 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15014079 | pubmed:month | May | lld:pubmed |
| pubmed-article:15014079 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15014079 | pubmed:author | pubmed-author:GuLiyaL | lld:pubmed |
| pubmed-article:15014079 | pubmed:author | pubmed-author:GuoShuangliS | lld:pubmed |
| pubmed-article:15014079 | pubmed:author | pubmed-author:LiGuo-MinGM | lld:pubmed |
| pubmed-article:15014079 | pubmed:author | pubmed-author:WangChunmeiC | lld:pubmed |
| pubmed-article:15014079 | pubmed:author | pubmed-author:YuanFenghuaF | lld:pubmed |
| pubmed-article:15014079 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15014079 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:15014079 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15014079 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15014079 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15014079 | pubmed:pagination | 20935-40 | lld:pubmed |
| pubmed-article:15014079 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15014079 | pubmed:meshHeading | pubmed-meshheading:15014079... | lld:pubmed |
| pubmed-article:15014079 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15014079 | pubmed:articleTitle | Evidence for involvement of HMGB1 protein in human DNA mismatch repair. | lld:pubmed |
| pubmed-article:15014079 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA. | lld:pubmed |
| pubmed-article:15014079 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15014079 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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