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pubmed-article:15013028pubmed:abstractTextIn the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. The animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. The results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1.) In haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal.lld:pubmed
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pubmed-article:15013028pubmed:pagination127-33lld:pubmed
pubmed-article:15013028pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15013028pubmed:articleTitleMonosialoganglioside (GM1) attenuates the behavioural effects of long-term haloperidol administration in supersensitive rats.lld:pubmed
pubmed-article:15013028pubmed:affiliationDepartment of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.lld:pubmed
pubmed-article:15013028pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15013028pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15013028pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed