| pubmed-article:15007094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:15007094 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:15007094 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15007094 | pubmed:dateCreated | 2004-3-16 | lld:pubmed |
| pubmed-article:15007094 | pubmed:abstractText | Toll-like receptors are important in the activation of innate immunity, and CD40 is a molecule critical for many T and B cell responses. Whereas agonists for either pathway have been used as vaccine adjuvants, we show that a combination of Toll-like receptor (TLR)7 and CD40 agonists synergize to stimulate CD8+ T cell responses 10-20-fold greater than the use of either agonist alone. Antigen-specific CD8+ T cells elicited from combination CD40/TLR7 treatment demonstrated both lytic activities and interferon (IFN)gamma production and an enhanced secondary response to antigenic challenge. Agonists for TLRs 2/6, 3, 4, and 9 also synergized with CD40 stimulation, demonstrating that synergy with the CD40 pathway is a property of TLR-derived stimuli in general. The CD8+ T cell expansion induced by CD40/TLR7 triggering was independent of CD4+ T cells, IFNgamma, and IL-12 but dependent on B7-mediated costimulation and surprisingly on type I IFN. These studies provide the rational basis for the use of TLR and CD40 agonists together as essential adjuvants to optimize vaccines designed to elicit protective or therapeutic immunity. | lld:pubmed |
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| pubmed-article:15007094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15007094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15007094 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15007094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15007094 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15007094 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15007094 | pubmed:author | pubmed-author:KedlRoss MRM | lld:pubmed |
| pubmed-article:15007094 | pubmed:author | pubmed-author:NoelleRandolp... | lld:pubmed |
