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pubmed-article:15006410pubmed:abstractTextA set of trimeric and tetrameric derivatives 6-11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discrete multimeric compounds are all significantly more antiviral than zanamivir and also show outstanding long-lasting protective activity when tested in mouse influenza infectivity experiments.lld:pubmed
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pubmed-article:15006410pubmed:articleTitleHighly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.lld:pubmed
pubmed-article:15006410pubmed:affiliationBiota Chemistry Laboratory, School of Chemistry, Monash University, PO Box 23, Victoria 3800, Australia. kwatson@edu.aulld:pubmed
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