| pubmed-article:15005819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15005819 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:15005819 | lifeskim:mentions | umls-concept:C0016157 | lld:lifeskim |
| pubmed-article:15005819 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15005819 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15005819 | pubmed:dateCreated | 2004-3-9 | lld:pubmed |
| pubmed-article:15005819 | pubmed:abstractText | We investigated the dietary influence of low and high levels of fish oil, supplemented with or without dietary cholesterol, on the plasma lipoprotein profile in Bio F1B hamsters, a model susceptible to diet-induced hyperlipidaemia. The MIX diet, a diet supplemented with a mixture of lard and safflower-seed oil, was used as the control diet to maintain the saturated MUFA and PUFA levels similar to the fish-oil diet. The animals were fed the specific diets for 2 weeks and fasted for 14 h before killing. The plasma from the animals fed high levels of fish oil was milky and rich in chylomicron-like particles. The plasma total cholesterol, VLDL- and LDL-cholesterol and -triacylglycerol concentrations were significantly higher, whereas HDL-cholesterol was lower in hamsters fed fish oil compared with the MIX-diet-fed hamsters. Increasing the amount of fat in the diet increased plasma lipids in both the fish-oil- and the MIX-diet-fed hamsters; however, this hyperlipidaemic effect of dietary fat level was greater in the hamsters fed the fish-oil diet. The hepatic lipid concentrations were not dramatically different between the fish-oil-fed and the MIX-diet-fed hamsters. However, the hepatic LDL-receptor mRNA levels were significantly low in the fish-oil-fed hamsters compared with the MIX-diet-fed hamsters. Increasing the amount of fish oil in the diet further decreased the hepatic LDL-receptor mRNA expression. It is concluded that F1B hamsters are susceptible to fish-oil-induced hyperlipidaemia, especially at high fat levels, and this increase is partially explained by the inhibition of hepatic LDL-receptor mRNA expression. | lld:pubmed |
| pubmed-article:15005819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15005819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15005819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15005819 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15005819 | pubmed:issn | 0007-1145 | lld:pubmed |
| pubmed-article:15005819 | pubmed:author | pubmed-author:CheemaSukhind... | lld:pubmed |
| pubmed-article:15005819 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:15005819 | pubmed:author | pubmed-author:DavisPhillip... | lld:pubmed |
| pubmed-article:15005819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15005819 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:15005819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15005819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15005819 | pubmed:pagination | 341-9 | lld:pubmed |
| pubmed-article:15005819 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15005819 | pubmed:meshHeading | pubmed-meshheading:15005819... | lld:pubmed |
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| pubmed-article:15005819 | pubmed:meshHeading | pubmed-meshheading:15005819... | lld:pubmed |
| pubmed-article:15005819 | pubmed:meshHeading | pubmed-meshheading:15005819... | lld:pubmed |
| pubmed-article:15005819 | pubmed:meshHeading | pubmed-meshheading:15005819... | lld:pubmed |
| pubmed-article:15005819 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15005819 | pubmed:articleTitle | Hyperlipidaemic effect of fish oil in Bio F1B hamsters. | lld:pubmed |
| pubmed-article:15005819 | pubmed:affiliation | Department of Biochemistry, Memorial University of Newfoundland, St John's, NL, Canada A1B 3X9. | lld:pubmed |
| pubmed-article:15005819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15005819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15005819 | lld:pubmed |
