| pubmed-article:15002060 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15002060 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:15002060 | lifeskim:mentions | umls-concept:C0221423 | lld:lifeskim |
| pubmed-article:15002060 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:15002060 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:15002060 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15002060 | pubmed:dateCreated | 2004-3-5 | lld:pubmed |
| pubmed-article:15002060 | pubmed:abstractText | Changes in both central and peripheral thyroid hormone (TH) metabolism occur during illness. These changes, known collectively as non-thyroidal illness, are apparently mediated by the proinflammatory cytokines IL-6, TNFalpha and IFNgamma. IL-12 is involved in regulation of IFNgamma and TNFalpha. The aim of this study was to evaluate the role of IL-12 in TH metabolism during illness. We studied TH metabolism both centrally (in the pituitary) and peripherally (in the liver) in IL-12 knock-out (IL-12 (-/-)) and wild type (WT) mice during illness induced by administration of bacterial endotoxin (LPS). LPS induced a similar decrease in serum T (3), T (4) and liver 5'-DI mRNA expression in IL-12 (-/-) and WT mice with the exception of a smaller reduction of serum T (4) in IL-12 (-/-) mice. In the pituitary, the LPS-induced decline in 5'-DI activity in WT mice was not observed in IL-12 (-/-) mice (p < 0.001), whereas the decrease in DII activity tended to be smaller in IL-12 (-/-) mice (p = 0.066). The lower decrease in pituitary activity of both DI and DII in IL-12 (-/-) mice is possibly related to the lower LPS-induced T (4) decrease. In conclusion, IL-12 is involved in the central regulation of the HPT axis during illness but not in the peripheral regulation. | lld:pubmed |
| pubmed-article:15002060 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15002060 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15002060 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15002060 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15002060 | pubmed:issn | 0018-5043 | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:BaumJJ | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:KöhrleJJ | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:WiersingaW... | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:Platvoet-ter... | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:BoelenAA | lld:pubmed |
| pubmed-article:15002060 | pubmed:author | pubmed-author:KwakkelJJ | lld:pubmed |
| pubmed-article:15002060 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15002060 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:15002060 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15002060 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15002060 | pubmed:pagination | 101-6 | lld:pubmed |
| pubmed-article:15002060 | pubmed:dateRevised | 2009-2-19 | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:meshHeading | pubmed-meshheading:15002060... | lld:pubmed |
| pubmed-article:15002060 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15002060 | pubmed:articleTitle | Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. | lld:pubmed |
| pubmed-article:15002060 | pubmed:affiliation | Department of Endocrinology & Metabolism, F5-171 Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. a.boelen@amc.uva.nl | lld:pubmed |
| pubmed-article:15002060 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15002060 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16160 | entrezgene:pubmed | pubmed-article:15002060 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15002060 | lld:pubmed |
