| pubmed-article:14999611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:14999611 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:14999611 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14999611 | pubmed:dateCreated | 2004-3-4 | lld:pubmed |
| pubmed-article:14999611 | pubmed:abstractText | T-1249 is a 39-aa synthetic peptide that inhibits fusion of human immunodeficiency virus (HIV) to the host target cell. A 14-day open-label, phase 1/2 dose-escalation monotherapy study of the safety and antiretroviral activity of T-1249 was performed on 115 HIV-1-infected adults. At baseline, the majority of the patients had advanced HIV disease (baseline median CD4(+) cell count, 57 cells/microL) and had extensive pretreatment (i.e., pre-T-1249) experience with antiretroviral medications (median, 11 antiretroviral drugs). Patients received T-1249 monotherapy by subcutaneous injection, for 14 days, at doses ranging from 6.25 to 192 mg/day. T-1249 was generally well tolerated, and no dose-limiting toxicity was identified. Injection-site reactions were the most commonly reported adverse event (57%). Dose-dependent decreases in plasma HIV-1 RNA load were observed; the median maximum change from baseline across dose groups ranged from -0.29 log(10) copies/mL (95% confidence interval [CI], -0.43 to -0.05 log(10) copies/mL) for the lowest dose to -1.96 log(10) copies/mL (95% CI, -2.02 to -1.37 copies/mL) for the highest dose. These results indicate that T-1249 is a potent new therapeutic agent for HIV-1 infection. | lld:pubmed |
| pubmed-article:14999611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14999611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14999611 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:14999611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14999611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14999611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14999611 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14999611 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:14999611 | pubmed:author | pubmed-author:GreenbergMich... | lld:pubmed |
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| pubmed-article:14999611 | pubmed:author | pubmed-author:ZhangYingY | lld:pubmed |
| pubmed-article:14999611 | pubmed:author | pubmed-author:GulickRoy MRM | lld:pubmed |
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| pubmed-article:14999611 | pubmed:author | pubmed-author:DiersAdriannA | lld:pubmed |
| pubmed-article:14999611 | pubmed:author | pubmed-author:MelbyThomasT | lld:pubmed |
| pubmed-article:14999611 | pubmed:author | pubmed-author:RusnakPamP | lld:pubmed |
| pubmed-article:14999611 | pubmed:author | pubmed-author:SpenceRebecca... | lld:pubmed |
| pubmed-article:14999611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14999611 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14999611 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:14999611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14999611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14999611 | pubmed:pagination | 1075-83 | lld:pubmed |
| pubmed-article:14999611 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:14999611 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14999611 | pubmed:articleTitle | Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIV. | lld:pubmed |
| pubmed-article:14999611 | pubmed:affiliation | Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. | lld:pubmed |
| pubmed-article:14999611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14999611 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:14999611 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:14999611 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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