| pubmed-article:1499860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C0027769 | lld:lifeskim |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C0047506 | lld:lifeskim |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:1499860 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:1499860 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1499860 | pubmed:dateCreated | 1992-9-17 | lld:pubmed |
| pubmed-article:1499860 | pubmed:abstractText | The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age was comparable in all groups, and the subjects had no evidence of coronary heart disease. Reduced heart-rate variation in a deep-breathing test was used as a criterion for autonomic neuropathy. Immediately after injection, the peak net influx rate of MIBG to myocardium was significantly (P less than 0.05) reduced in both diabetic groups. At 6 hr after MIBG injection, the MIBG uptake of the myocardium was significantly (P less than 0.05) smaller in the ANP+ group than in the control group. In the ANP- group, the MIBG uptake of the myocardium was between that of the ANP+ group and that of the control group. Our data show that reduced myocardial MIBG accumulation is associated with autonomic dysfunction in diabetic patients, but it can occur to a lesser extent also in diabetic patients without apparent autonomic neuropathy. The measurement of the myocardial MIBG accumulation is a promising new method to detect cardiac sympathetic nervous dysfunction in diabetic patients. | lld:pubmed |
| pubmed-article:1499860 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1499860 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499860 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1499860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1499860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1499860 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1499860 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:UusitupaMM | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:KuikkaJJ | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:LänsimiesEE | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:VanninenEE | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:MustonenJJ | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:MäntysaariMM | lld:pubmed |
| pubmed-article:1499860 | pubmed:author | pubmed-author:TahvanainenKK | lld:pubmed |
| pubmed-article:1499860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1499860 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:1499860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1499860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1499860 | pubmed:pagination | 1069-75 | lld:pubmed |
| pubmed-article:1499860 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1499860 | pubmed:meshHeading | pubmed-meshheading:1499860-... | lld:pubmed |
| pubmed-article:1499860 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1499860 | pubmed:articleTitle | Noninvasive detection of cardiac sympathetic nervous dysfunction in diabetic patients using [123I]metaiodobenzylguanidine. | lld:pubmed |
| pubmed-article:1499860 | pubmed:affiliation | Department of Clinical Physiology, Kuopio University Hospital, Finland. | lld:pubmed |
| pubmed-article:1499860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1499860 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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