| pubmed-article:14993594 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0010823 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0877837 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0963057 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C1880266 | lld:lifeskim |
| pubmed-article:14993594 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:14993594 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:14993594 | pubmed:dateCreated | 2004-3-10 | lld:pubmed |
| pubmed-article:14993594 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:abstractText | Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen. Type I IFN production can be induced both by unmethylated CpG-oligodeoxynucleotide and by double-stranded RNA. Here, we describe a codominant CpG-ODN unresponsive phenotype that results from an N-ethyl-N-nitrosourea-induced missense mutation in the Tlr9 gene (Tlr9(CpG1)). Mice homozygous for the Tlr9(CpG1) allele are highly susceptible to mouse cytomegalovirus infection and show impaired infection-induced secretion of IFN-alpha/beta and natural killer cell activation. We also demonstrate that both the Toll-like receptor (TLR) 9 --> MyD88 and TLR3 --> Trif signaling pathways are activated in vivo on viral inoculation, and that each pathway contributes to innate defense against systemic viral infection. Whereas both pathways lead to type I IFN production, neither pathway offers full protection against mouse cytomegalovirus infection in the absence of the other. The Tlr9(CpG1) mutation alters a leucine-rich repeat motif and lies within a receptor domain that is conserved within the evolutionary cluster encompassing TLRs 7, 8, and 9. In other TLRs, including three mouse-specific TLRs described in this paper, the affected region is not represented. The phenotypic effect of the Tlr9(CpG1) allele thus points to a critical role for TLR9 in viral sensing and identifies a vulnerable amino acid within the ectodomain of three TLR proteins, essential for a ligand response. | lld:pubmed |
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| pubmed-article:14993594 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14993594 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14993594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14993594 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14993594 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14993594 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:LüZ BZB | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:BeutlerBruceB | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:FlavellRichar... | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:TabetaKoichiK | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:AlexopoulouLe... | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:GeorgelPhilip... | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:HoebeKasperK | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:GoodeJasonJ | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:JanssenEdithE | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:CrozatKarineK | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:MuddSuzanneS | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:ShamelLouisL | lld:pubmed |
| pubmed-article:14993594 | pubmed:author | pubmed-author:SovathSosathy... | lld:pubmed |
| pubmed-article:14993594 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14993594 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:14993594 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:14993594 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14993594 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14993594 | pubmed:pagination | 3516-21 | lld:pubmed |
| pubmed-article:14993594 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14993594 | pubmed:meshHeading | pubmed-meshheading:14993594... | lld:pubmed |
| pubmed-article:14993594 | pubmed:meshHeading | pubmed-meshheading:14993594... | lld:pubmed |
| pubmed-article:14993594 | pubmed:meshHeading | pubmed-meshheading:14993594... | lld:pubmed |
| pubmed-article:14993594 | pubmed:meshHeading | pubmed-meshheading:14993594... | lld:pubmed |
| pubmed-article:14993594 | pubmed:meshHeading | pubmed-meshheading:14993594... | lld:pubmed |
