Linked Life Data

14991578

Source:http://linkedlifedata.com/resource/pubmed/id/14991578

Statements in which the resource exists.
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pubmed-article:14991578pubmed:abstractTextTo clarify the status of tax gene, we analyzed human T-cell leukemia virus type-I (HTLV-I) associated cell lines and fresh adult T-cell leukemia (ATL) cells. We compared 2 types of HTLV-I associated cell lines: one was derived from leukemic cells (leukemic cell line) and the other from nonleukemic cells (nonleukemic cell line). Although all nonleukemic cell lines expressed Tax, it could not be detected in 3 of 5 leukemic cell lines, in which nonsense mutation or deletion (60 bp) of tax genes, and DNA methylation in 5'-LTR were identified as the responsible changes. We found such genetic changes of the tax gene in 5 of 47 fresh ATL cases (11%). The tax gene transcripts could be detected in 14 of 41 fresh ATL cases (34%) by RT-PCR. In ATL cases with genetic changes that could not produce Tax protein, the tax gene was frequently transcribed, suggesting that such cells do not need the transcriptional silencing. Although DNA methylation of 5'-LTR was detected in the fresh ATL cases (19 of 28 cases; 68%), the complete methylation associated with transcriptional silencing was observed only in 4 cases. Since partial methylation could not silence the transcription, and the tax gene transcription was not detected in 27 of 41 cases (66%), the epigenetic change(s) other than DNA methylation is considered to play an important role in the silencing.lld:pubmed
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pubmed-article:14991578pubmed:authorpubmed-author:MatsuokaMasao...lld:pubmed
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pubmed-article:14991578pubmed:authorpubmed-author:YasunagaJun-I...lld:pubmed
pubmed-article:14991578pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:14991578pubmed:pagination559-67lld:pubmed
pubmed-article:14991578pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:14991578pubmed:articleTitleGenetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells.lld:pubmed
pubmed-article:14991578pubmed:affiliationInstitute for Virus Research, Kyoto University, Kyoto, Japan.lld:pubmed
pubmed-article:14991578pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14991578pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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