| pubmed-article:14990582 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C1439296 | lld:lifeskim |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C0001516 | lld:lifeskim |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:14990582 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:14990582 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:14990582 | pubmed:dateCreated | 2004-5-4 | lld:pubmed |
| pubmed-article:14990582 | pubmed:abstractText | It was recently shown that individuals carrying the naturally occurring mutant CX3CR1-Ile(249)-Met(280) (hereafter called CX3CR1-IM) have a lower risk of cardiovascular disease than individuals homozygous for the wild-type CX3CR1-Val(249)-Thr(280) (CX3CR1-VT). We report here that peripheral blood mononuclear cells (PBMC) from individuals with the CX3CR1-IM haplotype adhered more potently to membrane-bound CX3CL1 than did PBMC from homozygous CX3CR1-VT donors. Similar excess adhesion was observed with CX3CR1-IM-transfected human embryonic kidney (HEK) cell lines tested with two different methods: the parallel plate laminar flow chamber and the dual pipette aspiration technique. Suppression of the extra adhesion in the presence of pertussis toxin indicates that G-protein mediated the underlying transduction pathway, in contrast to the G-protein-independent adhesion previously described for CX3CR1-VT. Surprisingly, HEK and PBMC that expressed CX3CR1-IM and -VT were indistinguishable when tested with the soluble form of CX3CL1 for chemotaxis, calcium release, and binding capacity. In conclusion, only the membrane-anchored form of CX3CL1 functionally discriminated between these two allelic isoforms of CX3CR1. These results suggest that each form of this ligand may lead to a different signaling pathway. The extra adhesion of CX3CR1-IM may be related to immune defenses and to atherogenesis, both of which depend substantially on adhesive intercellular events. | lld:pubmed |
| pubmed-article:14990582 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14990582 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990582 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14990582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14990582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990582 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14990582 | pubmed:month | May | lld:pubmed |
| pubmed-article:14990582 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:DebréPatriceP | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:GarinAlexandr... | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:DeterrePhilip... | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:CombadièreChr... | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:PincetFrédéri... | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:TarantinoNadi... | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:DaoudiMehdiM | lld:pubmed |
| pubmed-article:14990582 | pubmed:author | pubmed-author:LavergneElise... | lld:pubmed |
| pubmed-article:14990582 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14990582 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:14990582 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:14990582 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14990582 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14990582 | pubmed:pagination | 19649-57 | lld:pubmed |
| pubmed-article:14990582 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14990582 | pubmed:meshHeading | pubmed-meshheading:14990582... | lld:pubmed |
| pubmed-article:14990582 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14990582 | pubmed:articleTitle | Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1. | lld:pubmed |
| pubmed-article:14990582 | pubmed:affiliation | Laboratoire d'Immunologie Cellulaire, INSERM U543, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, 75013 Paris, France. | lld:pubmed |
| pubmed-article:14990582 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14990582 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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