| pubmed-article:14990509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C0015352 | lld:lifeskim |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:14990509 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:14990509 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14990509 | pubmed:dateCreated | 2004-3-1 | lld:pubmed |
| pubmed-article:14990509 | pubmed:abstractText | Extracellular local field potentials are usually modeled as arising from a set of current sources embedded in a homogeneous extracellular medium. Although this formalism can successfully model several properties of extracellular local field potentials, it does not account for their frequency-dependent attenuation with distance, a property essential to correctly model extracellular spikes. Here we derive expressions for the extracellular potential that include this frequency-dependent attenuation. We first show that, if the extracellular conductivity is nonhomogeneous, there is induction of nonhomogeneous charge densities that may result in a low-pass filter. We next derive a simplified model consisting of a punctual (or spherical) current source with spherically symmetric conductivity/permittivity gradients around the source. We analyze the effect of different radial profiles of conductivity and permittivity on the frequency-filtering behavior of this model. We show that this simple model generally displays low-pass filtering behavior, in which fast electrical events (such as Na(+)-mediated action potentials) attenuate very steeply with distance, whereas slower (K(+)-mediated) events propagate over larger distances in extracellular space, in qualitative agreement with experimental observations. This simple model can be used to obtain frequency-dependent extracellular field potentials without taking into account explicitly the complex folding of extracellular space. | lld:pubmed |
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| pubmed-article:14990509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14990509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990509 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14990509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14990509 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14990509 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:14990509 | pubmed:author | pubmed-author:DestexheAlain... | lld:pubmed |
| pubmed-article:14990509 | pubmed:author | pubmed-author:BédardClaudeC | lld:pubmed |
| pubmed-article:14990509 | pubmed:author | pubmed-author:KrögerHelmutH | lld:pubmed |
| pubmed-article:14990509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14990509 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:14990509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14990509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14990509 | pubmed:pagination | 1829-42 | lld:pubmed |
| pubmed-article:14990509 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
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| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:meshHeading | pubmed-meshheading:14990509... | lld:pubmed |
| pubmed-article:14990509 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14990509 | pubmed:articleTitle | Modeling extracellular field potentials and the frequency-filtering properties of extracellular space. | lld:pubmed |
| pubmed-article:14990509 | pubmed:affiliation | Département de Physique, Université Laval, Québec, Québec G1K 7P4, Canada. | lld:pubmed |
| pubmed-article:14990509 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14990509 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14990509 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:14990509 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| pubmed-article:14990509 | pubmed:publicationType | Validation Studies | lld:pubmed |
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