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pubmed-article:14984517pubmed:dateCreated2004-2-26lld:pubmed
pubmed-article:14984517pubmed:abstractTextThe aim of this study was to investigate the pharmacokinetics of desflurane uptake into the brain and body by comparing desflurane concentrations in internal jugular-bulb blood (Jdes), arterial blood (Ades) and pulmonary arterial blood (PAdes) at a fixed inspired desflurane concentration. Thirteen patients (aged 42-72 years) undergoing coronary artery bypass grafting surgery were enrolled in this study. They were anaesthetised using a constant 5% inspired desflurane concentration (CIdes) during the first hour of anaesthesia. Under constant volume-controlled ventilation, CIdes and end-tidal desflurane (CEdes) were measured with an infrared analyser. The desflurane concentration in the blood was analysed using gas chromatography, and cardiac output was measured using an Opti-Q pulmonary artery catheter. It took 24 min for the Jdes to equilibrate with Ades. Both CIdes-CEdes and Ades-PAdes gradients persisted during the study period. There was no further uptake of desflurane into the brain after 24 min but there was near-constant uptake into the body.lld:pubmed
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pubmed-article:14984517pubmed:authorpubmed-author:TsaiC SCSlld:pubmed
pubmed-article:14984517pubmed:authorpubmed-author:LinC YCYlld:pubmed
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pubmed-article:14984517pubmed:volume59lld:pubmed
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pubmed-article:14984517pubmed:pagination216-21lld:pubmed
pubmed-article:14984517pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:14984517pubmed:year2004lld:pubmed
pubmed-article:14984517pubmed:articleTitlePharmacokinetics of desflurane uptake into the brain and body.lld:pubmed
pubmed-article:14984517pubmed:affiliationDepartment of Anaesthesiology, Tri-Service General Hospital, Taipei, Taiwan.lld:pubmed
pubmed-article:14984517pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14984517pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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