| pubmed-article:14980658 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14980658 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:14980658 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:14980658 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:14980658 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:14980658 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:14980658 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14980658 | pubmed:dateCreated | 2004-2-24 | lld:pubmed |
| pubmed-article:14980658 | pubmed:abstractText | A series of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives were synthesized and their anticancer cytotoxicity were evaluated in in vitro assay. It was found that the bulky aryl functionality in the 5-position of the 2-cyanoimino-4-imidazolidinone compounds was essential for the cytotoxicity of these heterocyclic compounds. Some of the derivatives exhibited modest cytotoxicity against a variety of cancer cell lines. One of the derivatives, [1-[6-(4-chlorophenoxy)hexyl]-5-oxo-4-phenyl-3-(4-pyridyl)tetrahydro-1H-2-imidazolyliden]aminomethanenitrile (Compound 11), exhibited the most potent cytotoxic activity with IC(50) in the nanomolar range. The cytotoxicity of these derivatives was selection with no apparent toxic effect toward normal fibroblasts. | lld:pubmed |
| pubmed-article:14980658 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14980658 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14980658 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14980658 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14980658 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14980658 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14980658 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14980658 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14980658 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:ShiaKak-ShanK... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:ChangChung-Mi... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:ChernJyh-Haur... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:LeeChung-ChiC... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:LeeYen-ChunYC | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:TsengHuan-YiH... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:TaiChia-Liang... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:LinYing-TingY... | lld:pubmed |
| pubmed-article:14980658 | pubmed:author | pubmed-author:ChangChih-Shi... | lld:pubmed |
| pubmed-article:14980658 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14980658 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:14980658 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:14980658 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14980658 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14980658 | pubmed:pagination | 1169-72 | lld:pubmed |
| pubmed-article:14980658 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:meshHeading | pubmed-meshheading:14980658... | lld:pubmed |
| pubmed-article:14980658 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14980658 | pubmed:articleTitle | Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives. | lld:pubmed |
| pubmed-article:14980658 | pubmed:affiliation | Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei 114, Taiwan. jhchen@nhri.org.tw | lld:pubmed |
| pubmed-article:14980658 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14980658 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14980658 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14980658 | lld:pubmed |
