| pubmed-article:14978357 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0012798 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:14978357 | lifeskim:mentions | umls-concept:C0215638 | lld:lifeskim |
| pubmed-article:14978357 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14978357 | pubmed:dateCreated | 2004-2-23 | lld:pubmed |
| pubmed-article:14978357 | pubmed:abstractText | Sairei-to (TJ-114), a Japanese traditional medicine, has been used clinically for the treatment of various edematous disorders. The inhibitory effect on edema may be dependent on the diuretic response to TJ-114. This study was conducted to clarify the mechanism of diuresis. Pentobarbital-anesthetized rats were infused with a saline solution intravenously (0.4 mL/30 min). Urine was collected through a bladder cannula for 30 min. Intraduodenal administration of TJ-114 (0.5 - 1.5 g/kg) resulted in a dose-dependent increase of urine volume with insignificant urinary sodium excretion and significant urea excretion, but no effect on mean arterial blood pressure. Furthermore, TJ-114 significantly increased urinary levels of NO(2) + NO(3). In addition, intraperitoneal pre-treatment with 6 mg/kg of N(G)-nitro-L-arginine methyl ester inhibited the increase in urine volume, urinary urea excretion, and urinary levels of NO(2) + NO(3) in the rats treated with TJ-114. These results suggest that TJ-114 induces a diuretic response via production of NO. | lld:pubmed |
| pubmed-article:14978357 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14978357 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978357 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14978357 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14978357 | pubmed:issn | 1347-8613 | lld:pubmed |
| pubmed-article:14978357 | pubmed:author | pubmed-author:GotoKazuhiroK | lld:pubmed |
| pubmed-article:14978357 | pubmed:author | pubmed-author:TakedaShuichi... | lld:pubmed |
| pubmed-article:14978357 | pubmed:author | pubmed-author:AburadaMasaki... | lld:pubmed |
| pubmed-article:14978357 | pubmed:author | pubmed-author:FujitsukaNaok... | lld:pubmed |
| pubmed-article:14978357 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14978357 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:14978357 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14978357 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14978357 | pubmed:pagination | 185-91 | lld:pubmed |
| pubmed-article:14978357 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
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| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:meshHeading | pubmed-meshheading:14978357... | lld:pubmed |
| pubmed-article:14978357 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14978357 | pubmed:articleTitle | The diuretic effect of Sairei-to is mediated by nitric oxide production in pentobarbital-anesthetized rats. | lld:pubmed |
| pubmed-article:14978357 | pubmed:affiliation | Medicinal Evaluation Laboratory, Tsumura Research Institute, Ibaraki, Japan. fujitsuka_naoki@mail.tsumura.co.jp | lld:pubmed |
| pubmed-article:14978357 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14978357 | pubmed:publicationType | Comparative Study | lld:pubmed |
