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pubmed-article:1497801pubmed:abstractTextThe coding sequences as well as 5'- and 3'-flanking sequences of the Syrian hamster c-Ha-ras gene were deduced from cDNA clones derived from embryo fibroblast cell lines. Sequences of introns B, C, and D were obtained from genomic DNA after amplification by the polymerase chain reaction. Sequence comparisons with rat, mouse, and human c-Ha-ras genes revealed a high degree of homology. One of 12 cDNA clones contained intron-D-exon (IDX) sequences due to alternative splicing that would encode a p19 Ha-ras gene product. Conservation between species suggests a functional role for the IDX, possibly as a negative control of p21 Ha-ras expression.lld:pubmed
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pubmed-article:1497801pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1497801pubmed:articleTitleCharacterization of the Syrian hamster c-Ha-ras gene and intron-D-exon transcript.lld:pubmed
pubmed-article:1497801pubmed:affiliationLaboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.lld:pubmed
pubmed-article:1497801pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1497801pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:1497801pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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