| pubmed-article:14978013 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C1335877 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C0023690 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C1413247 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C1421876 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:14978013 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:14978013 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14978013 | pubmed:dateCreated | 2004-2-23 | lld:pubmed |
| pubmed-article:14978013 | pubmed:abstractText | Activation-induced cytidine deaminase (AID) is an inducible gene that plays an important role in class switch recombination, somatic hypermutation and gene conversion in B cells. We examined the regulation of AID gene expression in human and mouse B cells by IL-4 and CD40 ligation. IL-4 by itself and, to a much lesser extent, CD40 ligation induced AID mRNA expression in primary B cells. The two stimuli strongly synergized in inducing AID mRNA and protein expression. IL-4 induced STAT6 binding to a site in the 5' upstream region of the AID gene, while CD40 ligation induced NFkappaB binding to two sites in that region. B cells from STAT6-/- mice failed to up-regulate AID in response to IL-4, while B cells from p50-/- mice were impaired in their ability to up-regulate AID in response to CD40 ligation and IL-4. These results suggest that signals delivered via CD40 that activate NFkappaB synergize with signals delivered via the IL-4 receptor that activate STAT6 to induce optimal AID gene expression. | lld:pubmed |
| pubmed-article:14978013 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978013 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978013 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14978013 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978013 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14978013 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14978013 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14978013 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:14978013 | pubmed:author | pubmed-author:AltFrederick... | lld:pubmed |
| pubmed-article:14978013 | pubmed:author | pubmed-author:GehaRaif SRS | lld:pubmed |
| pubmed-article:14978013 | pubmed:author | pubmed-author:DedeogluFatma... | lld:pubmed |
| pubmed-article:14978013 | pubmed:author | pubmed-author:ChaudhuriJaya... | lld:pubmed |
| pubmed-article:14978013 | pubmed:author | pubmed-author:HorwitzBruceB | lld:pubmed |
| pubmed-article:14978013 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14978013 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:14978013 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14978013 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14978013 | pubmed:pagination | 395-404 | lld:pubmed |
| pubmed-article:14978013 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:14978013 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14978013 | pubmed:articleTitle | Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. | lld:pubmed |
| pubmed-article:14978013 | pubmed:affiliation | Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14978013 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14978013 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14978013 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:20852 | entrezgene:pubmed | pubmed-article:14978013 | lld:entrezgene |
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