| pubmed-article:14977962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0024530 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0242723 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0444659 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:14977962 | lifeskim:mentions | umls-concept:C0205232 | lld:lifeskim |
| pubmed-article:14977962 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14977962 | pubmed:dateCreated | 2004-2-23 | lld:pubmed |
| pubmed-article:14977962 | pubmed:abstractText | Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-1(19), may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition enzyme-linked immunosorbent assay and antibody binding to wild-type and mutated recombinant proteins, we show that there are marked variations between individuals in the fine specificity of naturally acquired anti-MSP-1(19) antibodies. Furthermore, although neither the prevalence nor the concentration of total anti-MSP-1(19) antibodies was associated with resistance to malaria in African children, significant associations were observed between antibody fine specificity and subsequent risk of infection and high-density parasitemia during a follow-up period. Thus, the fine specificity of naturally acquired human anti-MSP-1(19) antibodies is crucial in determining their function. Future field studies, including the evaluation of PfMSP-1 vaccine trials, should include assays that explore antibody fine specificity as well as titer. | lld:pubmed |
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| pubmed-article:14977962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14977962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977962 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14977962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14977962 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14977962 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:HolderAnthony... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:RileyEleanor... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:ToddJamesJ | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:OkechBrenda... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:EgwangThomas... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:CorranPatrick... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:Joynson-Hicks... | lld:pubmed |
| pubmed-article:14977962 | pubmed:author | pubmed-author:UthaipibullCh... | lld:pubmed |
| pubmed-article:14977962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14977962 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:14977962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14977962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14977962 | pubmed:pagination | 1557-67 | lld:pubmed |
| pubmed-article:14977962 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14977962 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14977962 | pubmed:articleTitle | Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. | lld:pubmed |
| pubmed-article:14977962 | pubmed:affiliation | Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, National Institute for Medical Research, Mill Hill, London, United Kingdom. | lld:pubmed |
| pubmed-article:14977962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14977962 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:14977962 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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