| pubmed-article:14977921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C0148199 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C1539745 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C1820163 | lld:lifeskim |
| pubmed-article:14977921 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:14977921 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14977921 | pubmed:dateCreated | 2004-3-8 | lld:pubmed |
| pubmed-article:14977921 | pubmed:abstractText | Semaphorins, originally identified as axon guidance facto s in the nervous system, play integral roles in organogenesis. Here, we demonstrate a critical involvement of Sema6D in cardiac morphogenesis. Ectopic expression of Sema6D o RNA interference against Sema6D induces expansion or narrowing of the ventricular chamber, respectively, during chick embryonic development. Sema6D also exerts region-specific activities on cardiac explants, a migration-promoting activity on outgrowing cells from the conotruncal segment, and a migration-inhibitory activity on those from the ventricle. Plexin-A1 mediates these activities as the major Sema6D-binding receptor. Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in the conotruncal segment or with Off-track in the ventricle segment; these complexes are responsible for the effects of Sema6D on the respective regions. Thus, the differential association of Plexin-A1 with additional receptor components entitles Sema6D to exert distinct biological activities at adjacent regions. This is crucial for complex cardiac morphogenesis. | lld:pubmed |
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| pubmed-article:14977921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14977921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14977921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14977921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14977921 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14977921 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:ZhangHongH | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:KikutaniHitos... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:HoriMasatsugu... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:FujisawaHajim... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:SutoFumikazuF | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:TakegaharaNor... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:KumanogohAtsu... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:AokiKazuhiroK | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:KameiJunkoJ | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:ToyofukuToshi... | lld:pubmed |
| pubmed-article:14977921 | pubmed:author | pubmed-author:YabukiMasanor... | lld:pubmed |
| pubmed-article:14977921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14977921 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14977921 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:14977921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14977921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14977921 | pubmed:pagination | 435-47 | lld:pubmed |
| pubmed-article:14977921 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:meshHeading | pubmed-meshheading:14977921... | lld:pubmed |
| pubmed-article:14977921 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14977921 | pubmed:articleTitle | Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. | lld:pubmed |
| pubmed-article:14977921 | pubmed:affiliation | Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:14977921 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14977921 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
