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pubmed-article:14975149pubmed:abstractTextThe correlations between systolic blood pressure (SBP) and total cholesterol levels (CHOL) might result from genetic or environmental factors that determine variation in the phenotypes and are shared by family members. Based on 330 nuclear families in the Framingham Heart Study, we used a multivariate normal model, implemented in the software FISHER, to estimate genetic and shared environmental components of variation and genetic and shared environmental correlation between the phenotypes. The natural logarithm of the phenotypes measured at the last visit in both Cohort 1 and 2 was used in the analyses. The antihypertensive treatment effect was corrected before adjustment of the systolic blood pressure for age, sex, and cohort.lld:pubmed
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pubmed-article:14975149pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:14975149pubmed:articleTitleBivariate variance-component analysis, with application to systolic blood pressure and total cholesterol levels in the Framingham Heart Study.lld:pubmed
pubmed-article:14975149pubmed:affiliationCentre for Genetic Epidemiology, School of Population Health, The University of Melbourne, Parkville, Australia. j.cui@unimelb.edu.aulld:pubmed
pubmed-article:14975149pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14975149pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:14975149pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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