| pubmed-article:14967922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14967922 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14967922 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:14967922 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:14967922 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:14967922 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:14967922 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14967922 | pubmed:dateCreated | 2004-2-17 | lld:pubmed |
| pubmed-article:14967922 | pubmed:abstractText | The effect of interferon-tau on in vitro development of bovine embryos was investigated. After in vitro fertilization, embryos developed to the morula stage were cultured for 3 days in TCM-199 or CR1 medium containing BSA or FCS supplemented with or without recombinant IFN-tau produced by a baculovirus expression system. Addition of baculovirus-expressed IFN-tau (100 ng/ml) significantly promoted development to the blastocyst stage in both culture media. Addition of E. coli expressed IFN-tau (2 microg/ml) also significantly promoted the embryonic development. Supplementation of BSA or FCS did not affect the growth-promoting effect of IFN-tau. To determine whether the growth-promoting effect of IFN-tau is related to the interferon type I receptors that bind to type I interferon such as IFN-alpha, embryos were cultured with IFN-alpha. Although IFN-alpha significantly promoted the development, a much higher concentration (25 microg/ml) was required than IFN-tau. A reverse transcription polymerase chain reaction analysis revealed the expression of mRNA encoded type-I IFN receptor subunit from morula to blastocyst stage embryos. The overall results suggest a novel function for IFNs in promoting embryonic development and the effect may be related to type-I IFN receptor expressed in the early stages of preimplantation embryos. | lld:pubmed |
| pubmed-article:14967922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14967922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14967922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14967922 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:14967922 | pubmed:issn | 0916-8818 | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:WatanabeSatok... | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:TakahashiHito... | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:TakahashiMasa... | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:InumaruShigek... | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:OkudaKiyoshiK | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:YokomizoYuich... | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:OkanoAkiraA | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:HamanoSeizoS | lld:pubmed |
| pubmed-article:14967922 | pubmed:author | pubmed-author:GeshiMasayaM | lld:pubmed |
| pubmed-article:14967922 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14967922 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:14967922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14967922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14967922 | pubmed:pagination | 297-305 | lld:pubmed |
| pubmed-article:14967922 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:meshHeading | pubmed-meshheading:14967922... | lld:pubmed |
| pubmed-article:14967922 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14967922 | pubmed:articleTitle | Possible role of interferon-tau on in vitro development of bovine embryos. | lld:pubmed |
| pubmed-article:14967922 | pubmed:affiliation | National Agricultural Research Center for Kyushu Okinawa region, Kumamoto 861-1192, Japan. masashi@affrc.go.jp | lld:pubmed |
| pubmed-article:14967922 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14967922 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:14967922 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
