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pubmed-article:14966149pubmed:abstractTextDeclines in brain glucose metabolism have been described early in Alzheimer's disease (AD), and there is evidence that a genetic predisposition to AD contributes to accelerate this process. The epsilon 4 (e4) allele of the apolipoprotein E (ApoE) gene has been implicated as a major risk factor in this process. The aim of this FDG-PET study was to assess the ApoE e4 dose related effect on regional cerebral glucose metabolism (METglc) in clinical AD patients, with statistical voxel based methods.lld:pubmed
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pubmed-article:14966149pubmed:articleTitleBrain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease.lld:pubmed
pubmed-article:14966149pubmed:affiliationDepartment of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.lld:pubmed
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