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pubmed-article:14963283pubmed:abstractTextFibrinogen, plasminogen activator inhibitor-1, and other key proteins in the coagulation cascade have been implicated in the origin of cardiovascular disease. Polymorphisms in genes encoding these proteins have been associated with variability in plasma levels of these proteins. Carotid intimal medial thickness (IMT) is a heritable, quantitative measure of atherosclerosis that is predictive of subsequent myocardial infarction and stroke. We sought to test whether carotid IMT is associated with polymorphisms in several well-characterized genes in the hemostatic factor pathways.lld:pubmed
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pubmed-article:14963283pubmed:articleTitleAbsence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study.lld:pubmed
pubmed-article:14963283pubmed:affiliationNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Mass, USA.lld:pubmed
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pubmed-article:14963283pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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