| pubmed-article:1494042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:1494042 | lifeskim:mentions | umls-concept:C0935931 | lld:lifeskim |
| pubmed-article:1494042 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1494042 | pubmed:dateCreated | 1993-3-11 | lld:pubmed |
| pubmed-article:1494042 | pubmed:abstractText | An epidural application of kainic acid (KA) over the cerebral cortex in rat resulted in an extensive lesion in the ipsilateral cerebral cortex. This procedure elicited an accumulation of a large number of macrophages at the site of lesion covering a period of 4 weeks beginning 4 days after the KA application. The macrophages in the centre of lesion were characterized by abundant cytoplasm containing a variable number of lysosomes and phagosomes. Neurons at the same site were depleted during the period examined. They underwent degeneration following the KA treatment. With the monoclonal antibodies OX-42, OX-18 and OX-6, intense immunoreactivity was observed in these cells at the light and electron microscopic levels. Besides these antibodies, the cells were stained positively with the isolectin Griffonia simplicifolia (GSAI-B4). At the periphery of the lesion, many cells bearing the external morphology of microglia were also intensely stained with the GSAI-B4 and the monoclonal antibodies. It was concluded from this study that neuronal degeneration, caused by the excitotoxin KA, induced the accumulation of macrophages which exhibited CR3 receptors (marked by OX-42), MHC I antigen (marked by OX-18) and MHC Ia (marked by OX-6). The expression of these surface antigens may be related to their active phagocytic activity. The reaction with GSAI-B4 indicates the presence of specific lectin receptors on the macrophages which would serve a similar function. The present lectin histochemistry and immunohistochemical studies suggest that macrophages in the centre of the KA-induced lesion were derived from infiltrated monocytes while those at the periphery originated from the activation of local microglial cells. | lld:pubmed |
| pubmed-article:1494042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1494042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1494042 | pubmed:issn | 0021-8359 | lld:pubmed |
| pubmed-article:1494042 | pubmed:author | pubmed-author:KaurCC | lld:pubmed |
| pubmed-article:1494042 | pubmed:author | pubmed-author:LingE AEA | lld:pubmed |
| pubmed-article:1494042 | pubmed:author | pubmed-author:ChaoY HYH | lld:pubmed |
| pubmed-article:1494042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1494042 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:1494042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1494042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1494042 | pubmed:pagination | 645-52 | lld:pubmed |
| pubmed-article:1494042 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1494042 | pubmed:meshHeading | pubmed-meshheading:1494042-... | lld:pubmed |
| pubmed-article:1494042 | pubmed:meshHeading | pubmed-meshheading:1494042-... | lld:pubmed |
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| pubmed-article:1494042 | pubmed:meshHeading | pubmed-meshheading:1494042-... | lld:pubmed |
| pubmed-article:1494042 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1494042 | pubmed:articleTitle | Ultrastructural and immunocytochemical studies of macrophages in an excitotoxin induced lesion in the rat brain. | lld:pubmed |
| pubmed-article:1494042 | pubmed:affiliation | Department of Anatomy, Faculty of Medicine, National University of Singapore. | lld:pubmed |
| pubmed-article:1494042 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1494042 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
