| pubmed-article:1490484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0521378 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0007550 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C1705911 | lld:lifeskim |
| pubmed-article:1490484 | lifeskim:mentions | umls-concept:C2003855 | lld:lifeskim |
| pubmed-article:1490484 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1490484 | pubmed:dateCreated | 1993-3-2 | lld:pubmed |
| pubmed-article:1490484 | pubmed:abstractText | The plasma disposition kinetics and the biliary excretion kinetics of cefmetazole after i.v. administration to rats anaesthetized with pentobarbital sodium were studied. Parametric estimation was carried out using non-linear regression methods with uni- and bivariate analyses. On the basis of statistical criteria a two-compartment model was chosen as the most appropriate for fitting the plasma concentration data, establishing a mean half-life value of the slow disposition phase at around 13 min. Analysis of the plasma and biliary data revealed a mean value for the biliary excretion constant of 0.049 l/min and 0.113 l/min for the urinary excretion constant. The cumulative biliary excretion data showed a mean value of 36.25% of the dose administered. The relationship between the biliary excretion rates and plasma concentrations seems to point to a saturable mechanism of excretion. | lld:pubmed |
| pubmed-article:1490484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1490484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1490484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1490484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1490484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1490484 | pubmed:issn | 0378-7966 | lld:pubmed |
| pubmed-article:1490484 | pubmed:author | pubmed-author:GonzálezJJ | lld:pubmed |
| pubmed-article:1490484 | pubmed:author | pubmed-author:JiménezRR | lld:pubmed |
| pubmed-article:1490484 | pubmed:author | pubmed-author:MariñoE LEL | lld:pubmed |
| pubmed-article:1490484 | pubmed:author | pubmed-author:García-Agunde... | lld:pubmed |
| pubmed-article:1490484 | pubmed:author | pubmed-author:Fernández-Las... | lld:pubmed |
| pubmed-article:1490484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1490484 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:1490484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1490484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1490484 | pubmed:pagination | 167-73 | lld:pubmed |
| pubmed-article:1490484 | pubmed:dateRevised | 2011-2-2 | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:meshHeading | pubmed-meshheading:1490484-... | lld:pubmed |
| pubmed-article:1490484 | pubmed:articleTitle | Pharmacokinetic parameters from data relating to the plasma and biliary excretion kinetics of cefmetazole in rats. | lld:pubmed |
| pubmed-article:1490484 | pubmed:affiliation | Department of Pharmaceutics and Practical Pharmacy, University of Salamanca, Spain. | lld:pubmed |
| pubmed-article:1490484 | pubmed:publicationType | Journal Article | lld:pubmed |
