| pubmed-article:14766792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14766792 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:14766792 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:14766792 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:14766792 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:14766792 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14766792 | pubmed:dateCreated | 2004-3-31 | lld:pubmed |
| pubmed-article:14766792 | pubmed:abstractText | Nuclear factor (NF)-kappaB p50 protein is involved in promoting survival in hippocampal neurons after trimethyltin (TMT)-injury. In the current study, hippocampal NF-kappaB activity was examined and quantitated from transgenic kappaB-lacZ reporter mice after chemical-induced injury. NF-kappaB activity was localized primarily to hippocampal neurons and significantly elevated over that in saline-treated mice between 4 and 21 days after TMT injection. Seven days after TMT injection, a timepoint of elevated NF-kappaB activity, gene expression in the hippocampus was studied by microarray analysis through comparison of expression profiles between treated nontransgenic and p50-null mice with their saline-injected controls. Seventeen genes increased in nontransgenic TMT-treated mice relative to saline-treated as well as showing no increase in p50-null mice, indicating a role for p50 in their regulation. One of these genes, the Na+, K+-ATPase-gamma subunit, was detected in brain for the first time. Several of the genes modulated by NF-kappaB are potentially related to neuroplasticity, providing additional evidence that this transcription factor is a neuroprotective signal in the hippocampus. | lld:pubmed |
| pubmed-article:14766792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14766792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14766792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14766792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14766792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14766792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14766792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14766792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14766792 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:14766792 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:IsraëlAA | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:PennypackerK... | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:MémetSS | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:PattonG WGW | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:ButlerT LTL | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:KassedC ACA | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:NavidomskisM... | lld:pubmed |
| pubmed-article:14766792 | pubmed:author | pubmed-author:DemesquitaD... | lld:pubmed |
| pubmed-article:14766792 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14766792 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:14766792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14766792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14766792 | pubmed:pagination | 723-4 | lld:pubmed |
| pubmed-article:14766792 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
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| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
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| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:meshHeading | pubmed-meshheading:14766792... | lld:pubmed |
| pubmed-article:14766792 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14766792 | pubmed:articleTitle | Injury-induced NF-kappaB activation in the hippocampus: implications for neuronal survival. | lld:pubmed |
| pubmed-article:14766792 | pubmed:affiliation | Department of Pharmacology and Therapeutics, University of South Florida, Tampa, Florida 33612, USA. | lld:pubmed |
| pubmed-article:14766792 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14766792 | lld:pubmed |
