| pubmed-article:14764895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:14764895 | lifeskim:mentions | umls-concept:C1549649 | lld:lifeskim |
| pubmed-article:14764895 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:14764895 | pubmed:dateCreated | 2004-2-18 | lld:pubmed |
| pubmed-article:14764895 | pubmed:abstractText | Can CD4(+) and CD8(+) "memory" T cells that are generated and maintained in the context of low-level virus persistence protect, in the absence of antibody, against a repeat challenge with the same pathogen? Although immune T cells exert effective, long-term control of a persistent gamma-herpesvirus (gammaHV68) in Ig(-/-) microMT mice, subsequent exposure to a high dose of the same virus leads to further low-level replication in the lung. This lytic phase in the respiratory tract is dealt with effectively by the recall of memory T cells induced by a gammaHV68 recombinant (M3LacZ) that does not express the viral M3 chemokine binding protein. At least for the CD8(+) response, greater numbers of memory T cells confer enhanced protection in the M3LacZ-immune mice. However, neither WT gammaHV68 nor the minimally persistent M3LacZ primes the T cell response to the extent that a WT gammaHV68 challenge fails to establish latency in the microMT mice. Memory CD4(+) and CD8(+) T cells thus act together to limit gammaHV68 infection but are unable to provide absolute protection against a high-dose, homologous challenge. | lld:pubmed |
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| pubmed-article:14764895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14764895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14764895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14764895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14764895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14764895 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14764895 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:KoszinowskiUl... | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:LiuHaiyanH | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:AndreanskySam... | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:DohertyPeter... | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:EfstathiouSta... | lld:pubmed |
| pubmed-article:14764895 | pubmed:author | pubmed-author:AdlerHeikoH | lld:pubmed |
| pubmed-article:14764895 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14764895 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:14764895 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:14764895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14764895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14764895 | pubmed:pagination | 2017-22 | lld:pubmed |
| pubmed-article:14764895 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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