| pubmed-article:14747279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0025921 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0019475 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:14747279 | lifeskim:mentions | umls-concept:C0599781 | lld:lifeskim |
| pubmed-article:14747279 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14747279 | pubmed:dateCreated | 2004-1-28 | lld:pubmed |
| pubmed-article:14747279 | pubmed:abstractText | The aim of the present study was to determine the specific sites of impairment to muscle glucose uptake (MGU) in the insulin-resistant high-fat-fed, conscious C57BL/6J mouse. Wild type (WT) and hexokinase II overexpressing (HK(Tg)) mice were fed either a standard diet or high-fat diet and studied at 4 months of age. A carotid artery and jugular veins had catheters chronically implanted for sampling and infusions, respectively, and mice were allowed to recovery for at least 5 days. Mice were fasted for 5 h and underwent a hyperinsulinemic-euglycemic clamp or saline infusion for 120 min. Separate groups of mice were studied during 30-min sedentary or treadmill exercise periods. A bolus of 2-deoxy[(3)H]glucose was administered 25 min before the end of each study for determination of R(g), an index of tissue-specific glucose uptake. Fasting blood glucose was increased in high-fat compared with standard diet-fed WT (194 +/- 4 vs. 171 +/- 4 mg/dl) but not HK(Tg) (179 +/- 5 vs. 171 +/- 3 mg/dl) mice. High-fat feeding created hyperinsulinemia in both WT and HK(Tg) mice (58 +/- 8 and 77 +/- 15 micro U/ml) compared with standard diet-fed mice (21 +/- 2 and 20 +/- 1 micro U/ml). R(g) was not affected by genotype or diet during either saline infusion or sedentary conditions. HK II overexpression augmented insulin-stimulated R(g) in standard diet-fed but not high-fat-fed mice. Exercise-stimulated R(g) was impaired by high-fat feeding in WT mice, but this impairment was largely rectified in HK(Tg) mice. In conclusion, high-fat feeding impairs both insulin- and exercise-stimulated MGU, but only exercise-stimulated MGU was corrected by HK II overexpression. | lld:pubmed |
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| pubmed-article:14747279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14747279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14747279 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:14747279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14747279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14747279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14747279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14747279 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14747279 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:PencekR... | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:WassermanDavi... | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:GrannerDaryl... | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:FuegerPatrick... | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:BracyDeanna... | lld:pubmed |
| pubmed-article:14747279 | pubmed:author | pubmed-author:MalabananCarl... | lld:pubmed |
| pubmed-article:14747279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14747279 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:14747279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14747279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14747279 | pubmed:pagination | 306-14 | lld:pubmed |
| pubmed-article:14747279 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:14747279 | pubmed:meshHeading | pubmed-meshheading:14747279... | lld:pubmed |
| pubmed-article:14747279 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14747279 | pubmed:articleTitle | Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice. | lld:pubmed |
| pubmed-article:14747279 | pubmed:affiliation | Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. patrick.fueger@vanderbilt.edu | lld:pubmed |
| pubmed-article:14747279 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14747279 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14747279 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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