| pubmed-article:14746986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14746986 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:14746986 | lifeskim:mentions | umls-concept:C0017429 | lld:lifeskim |
| pubmed-article:14746986 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:14746986 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14746986 | pubmed:dateCreated | 2004-1-28 | lld:pubmed |
| pubmed-article:14746986 | pubmed:abstractText | Comparative analyses of ESTs and cDNAs with genomic DNA predict a high frequency of alternative splicing in human genes. However, there is an ongoing debate as to how many of these predicted splice variants are functional and how many are the result of aberrant splicing (or 'noise'). To address this question, we compared alternatively spliced cassette exons that are conserved between human and mouse with EST-predicted cassette exons that are not conserved in the mouse genome. Presumably, conserved exon-skipping events represent functional alternative splicing. We show that conserved (functional) cassette exons possess unique characteristics in size, repeat content and in their influence on the protein. By contrast, most non-conserved cassette exons do not share these characteristics. We conclude that a significant portion of cassette exons evident in EST databases is not functional, and might result from aberrant rather than regulated splicing. | lld:pubmed |
| pubmed-article:14746986 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14746986 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14746986 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14746986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14746986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14746986 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14746986 | pubmed:issn | 0168-9525 | lld:pubmed |
| pubmed-article:14746986 | pubmed:author | pubmed-author:TehY FYF | lld:pubmed |
| pubmed-article:14746986 | pubmed:author | pubmed-author:ShamirRonR | lld:pubmed |
| pubmed-article:14746986 | pubmed:author | pubmed-author:SorekRotemR | lld:pubmed |
| pubmed-article:14746986 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14746986 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:14746986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14746986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14746986 | pubmed:pagination | 68-71 | lld:pubmed |
| pubmed-article:14746986 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:meshHeading | pubmed-meshheading:14746986... | lld:pubmed |
| pubmed-article:14746986 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14746986 | pubmed:articleTitle | How prevalent is functional alternative splicing in the human genome? | lld:pubmed |
| pubmed-article:14746986 | pubmed:affiliation | Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel. | lld:pubmed |
| pubmed-article:14746986 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14746986 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14746986 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14746986 | lld:pubmed |
