| pubmed-article:1473147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0596963 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1473147 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:1473147 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1473147 | pubmed:dateCreated | 1993-2-3 | lld:pubmed |
| pubmed-article:1473147 | pubmed:abstractText | As a novel approach to studying the modulation of the polarized epithelial phenotype, we have expressed c-Fos and c-Myc estrogen receptor fusion proteins (c-FosER and c-MycER) in mammary epithelial cells. The hybrid proteins could be activated by estrogen for defined time periods and after the cells had achieved their fully polarized organization. Activation of c-MycER deregulated proliferation but did not affect epithelial polarity. Short-term activation of c-FosER induced the reversible loss of morphological and functional cell polarity. In contrast, long-term stimulation of c-FosER caused the cells to depolarize irreversibly, to invade collagen gels, and to undergo epithelial-fibroblastoid cell conversion. Our data suggest that Fos proteins are important in modulating the epithelial phenotype both in normal tissue development and in invasive processes. | lld:pubmed |
| pubmed-article:1473147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1473147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1473147 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1473147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1473147 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1473147 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:BergerJJ | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:SchwarzHH | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:BusslingerMM | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:BeugHH | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:LeitnerII | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:EilersMM | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:ReichmannEE | lld:pubmed |
| pubmed-article:1473147 | pubmed:author | pubmed-author:DeinerE MEM | lld:pubmed |
| pubmed-article:1473147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1473147 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:1473147 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:1473147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1473147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1473147 | pubmed:pagination | 1103-16 | lld:pubmed |
| pubmed-article:1473147 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:1473147 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1473147 | pubmed:articleTitle | Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. | lld:pubmed |
| pubmed-article:1473147 | pubmed:affiliation | Forschungsinstitut für Molekulare Pathologie, Wien, Austria. | lld:pubmed |
| pubmed-article:1473147 | pubmed:publicationType | Journal Article | lld:pubmed |
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