Linked Life Data

14718251

Source:http://linkedlifedata.com/resource/pubmed/id/14718251

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14718251rdf:typepubmed:Citationlld:pubmed
pubmed-article:14718251lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C2350570lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C1181031lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C0042401lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C0597357lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C0001128lld:lifeskim
pubmed-article:14718251lifeskim:mentionsumls-concept:C0086597lld:lifeskim
pubmed-article:14718251pubmed:issue3lld:pubmed
pubmed-article:14718251pubmed:dateCreated2004-2-6lld:pubmed
pubmed-article:14718251pubmed:abstractTextActivation of rat adenosine2A receptors (A2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs). Incubation of PGMV with a selective A2A R agonist, 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680; 100 microM), increased isolated PGMV EET levels to 7.57+/-1.53 ng mg-1 protein from 1.06+/-0.22 ng mg-1 protein in controls (P<0.05), without affecting hydroxyeicosatetraenoic acid (HETE) levels (10.8+/-0.69 vs 11.02+/-0.74 ng mg-1 protein). CGS 21680-stimulated EETs was abolished by preincubation with an A2A R antagonist, 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM241385) (100 microM). A selective epoxygenase inhibitor, methylsulfonyl-propargyloxyphenylhexanamide (MS-PPOH; 12 microM) prevented CGS 21680-induced increase in EETs, indicating inhibition of de novo synthesis of EETs. In pressurized (80 mmHg) renal arcuate arteries (110-130 microm) preconstricted with phenylephrine (20 nM), superfusion with CGS 21680 (0.01-10 microM) increased the internal diameter (i.d.) concentration-dependently; vasodilation was independent of nitric oxide and cyclooxygenase activity. CGS 21680 (10 microM) increased i.d. by 32+/-6 microm; vasodilation was prevented by inhibition of EET synthesis with MS-PPOH. Addition of 3 nM 5,6-EET, 8,9-EET and 11,12-EET increased i.d. by 53+/-9, 17+/-4 and 53+/-5 microm, respectively, whereas 14,15-EET was inactive. The responses to 5,6-EET were, however, significantly inhibited by indomethacin. We conclude that 11,12-EET is the likely mediator of A2A R-induced dilation of rat PGMV. Activation of A2A R coupled to de novo EET stimulation may represent an important mechanism in regulating preglomerular microvascular tone. British Journal of Pharmacology (2004) 141, 441-448. doi:10.1038/sj.bjp.0705640lld:pubmed
pubmed-article:14718251pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:languageenglld:pubmed
pubmed-article:14718251pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:citationSubsetIMlld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14718251pubmed:statusMEDLINElld:pubmed
pubmed-article:14718251pubmed:monthFeblld:pubmed
pubmed-article:14718251pubmed:issn0007-1188lld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:McGiffJ CJClld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:CarrollM AMAlld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:JiangHHlld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:FalckJ RJRlld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:ChengM KMKlld:pubmed
pubmed-article:14718251pubmed:authorpubmed-author:DoumadA BABlld:pubmed
pubmed-article:14718251pubmed:issnTypePrintlld:pubmed
pubmed-article:14718251pubmed:volume141lld:pubmed
pubmed-article:14718251pubmed:ownerNLMlld:pubmed
pubmed-article:14718251pubmed:authorsCompleteYlld:pubmed
pubmed-article:14718251pubmed:pagination441-8lld:pubmed
pubmed-article:14718251pubmed:dateRevised2010-11-18lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
pubmed-article:14718251pubmed:meshHeadingpubmed-meshheading:14718251...lld:pubmed
More...