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pubmed-article:14715419pubmed:abstractTextRecent studies have demonstrated the activation of skeletal muscle DNA fragmentation in some catabolic conditions. In an attempt to elucidate if sepsis (a catabolic state) was also associated with muscle apoptosis, sepsis was induced by cecal ligation and puncture, and the results clearly show an induction of DNA fragmentation in gastrocnemius muscle following the induction of the septic state. Administration of rolipram (an inhibitor of tumour necrosis factor-a (TNF-alpha) synthesis) to septic rats clearly prevented the increased DNA fragmentation, suggesting that TNF-alpha is involved in the activation of the apoptotic events in septic rat skeletal muscle.lld:pubmed
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pubmed-article:14715419pubmed:authorpubmed-author:López-Soriano...lld:pubmed
pubmed-article:14715419pubmed:authorpubmed-author:ArgilésJosep...lld:pubmed
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pubmed-article:14715419pubmed:authorpubmed-author:FiguerasMaite...lld:pubmed
pubmed-article:14715419pubmed:copyrightInfoCopyright John Libbey Eurotext 2003.lld:pubmed
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pubmed-article:14715419pubmed:volume14lld:pubmed
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pubmed-article:14715419pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:14715419pubmed:articleTitleSepsis induces DNA fragmentation in rat skeletal muscle.lld:pubmed
pubmed-article:14715419pubmed:affiliationDepartament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain.lld:pubmed
pubmed-article:14715419pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14715419pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed