| pubmed-article:14711650 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14711650 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:14711650 | lifeskim:mentions | umls-concept:C0524581 | lld:lifeskim |
| pubmed-article:14711650 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:14711650 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14711650 | pubmed:dateCreated | 2004-1-8 | lld:pubmed |
| pubmed-article:14711650 | pubmed:abstractText | The 3-hydroxy fatty acids (3-OHFAs) in lipopolysaccharides (LPS) play an important role in determining endotoxin activity, and childhood exposure to endotoxin has recently been associated with reduced risk of atopic diseases. To characterize the 3-OHFAs in house dust (HD), we used gas chromatography-mass spectrometry to assay 190 HD samples. Dust from beds, bedroom floors, family rooms, and kitchen floors was collected as part of a birth cohort study of childhood asthma (study 1) and a longitudinal study of home allergen and endotoxin (study 2). We also measured endotoxin activity with a Limulus assay and computed specific activity (endotoxin activity per nanomole of LPS). Longer-chain (C(16:0) and C(18:0)) 3-OHFAs were predominant in HD compared with short-chain (C(10:0), C(12:0), and C(14:0)) acids. Endotoxin activity was positively correlated with short-chain 3-OHFAs in both studies. In study 2, 3-OH C(16:0) was negatively correlated and 3-OH C(18:0) was not correlated with endotoxin activity, consistent with previous findings that the Limulus assay responds preferentially to LPS containing short-chain 3-OHFAs. Kitchen dust contained the highest concentrations of 3-OH C(10:0), the highest endotoxin activities, and the highest specific activities (P < 0.03). Bed dust contained the largest amounts of long-chain 3-OHFAs, the highest concentrations of LPS, and the lowest specific activities. Apartments had significantly different types of LPS (P = 0.03) compared with single-family homes in study 2. These data suggest that the Limulus assay may underestimate exposure to certain types of LPS. Because nontoxic LPS may have immune modulating effects, analysis of 3-OHFAs may be useful in epidemiologic studies. | lld:pubmed |
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| pubmed-article:14711650 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14711650 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14711650 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14711650 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14711650 | pubmed:issn | 0099-2240 | lld:pubmed |
| pubmed-article:14711650 | pubmed:author | pubmed-author:LarssonLennar... | lld:pubmed |
| pubmed-article:14711650 | pubmed:author | pubmed-author:GoldDiane RDR | lld:pubmed |
| pubmed-article:14711650 | pubmed:author | pubmed-author:SzponarBogumi... | lld:pubmed |
| pubmed-article:14711650 | pubmed:author | pubmed-author:MiltonDonald... | lld:pubmed |
| pubmed-article:14711650 | pubmed:author | pubmed-author:ParkJu-Hyeong... | lld:pubmed |
| pubmed-article:14711650 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14711650 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:14711650 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14711650 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14711650 | pubmed:pagination | 262-7 | lld:pubmed |
| pubmed-article:14711650 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14711650 | pubmed:meshHeading | pubmed-meshheading:14711650... | lld:pubmed |
| pubmed-article:14711650 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14711650 | pubmed:articleTitle | Characterization of lipopolysaccharides present in settled house dust. | lld:pubmed |
| pubmed-article:14711650 | pubmed:affiliation | Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. | lld:pubmed |
| pubmed-article:14711650 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14711650 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14711650 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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