| pubmed-article:14709909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:14709909 | lifeskim:mentions | umls-concept:C0311404 | lld:lifeskim |
| pubmed-article:14709909 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14709909 | pubmed:dateCreated | 2004-1-7 | lld:pubmed |
| pubmed-article:14709909 | pubmed:abstractText | Susceptibility to oxidative stress by X-ray irradiation was examined in splenic cells of BDF1 mouse and fetal human lung fibroblasts, TIG-7. Survival rates of splenic cells irradiated with X-rays were lower than those of TIG-7 cells irradiated similarly. The content of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) immediately after X-ray irradiation in the DNA of splenic cells increased until 2 Gy irradiation, but remained constant above 2 Gy. The 8-oxodG contents rose in proportion to the dose of X-rays in TIG-7 cells. Although the survival rate of splenic cells exposed to 1 Gy irradiation decreased with time, the survival rate of TIG-7 cells remained unchanged. The 8-oxodG content in splenic cells irradiated with X-rays did not decrease even 48 h after irradiation, while that in TIG-7 cells decreased with time, and recovered to the pre-irradiation level after 48 h. A DNA ladder was observed in splenic cells 2 h after X-ray irradiation, but the ladder was not found in fibroblasts. Furthermore, caspase-3 activity increased after X-ray irradiation of splenic cells. These results indicate that splenic cells are sensitive to oxidative stress induced by X-ray irradiation and that splenic cells damaged by even low doses of X-rays are removed through apoptosis rather than by a repair pathway. | lld:pubmed |
| pubmed-article:14709909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14709909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14709909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14709909 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14709909 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:14709909 | pubmed:author | pubmed-author:KanekoTakaoT | lld:pubmed |
| pubmed-article:14709909 | pubmed:author | pubmed-author:TaharaShoichi... | lld:pubmed |
| pubmed-article:14709909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14709909 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:14709909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14709909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14709909 | pubmed:pagination | 105-8 | lld:pubmed |
| pubmed-article:14709909 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
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| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
| pubmed-article:14709909 | pubmed:meshHeading | pubmed-meshheading:14709909... | lld:pubmed |
| pubmed-article:14709909 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14709909 | pubmed:articleTitle | Susceptibility of mouse splenic cells to oxidative DNA damage by x-ray irradiation. | lld:pubmed |
| pubmed-article:14709909 | pubmed:affiliation | Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. | lld:pubmed |
| pubmed-article:14709909 | pubmed:publicationType | Journal Article | lld:pubmed |
