| pubmed-article:14707172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0003232 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0335038 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0920472 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0279516 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0220922 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0449445 | lld:lifeskim |
| pubmed-article:14707172 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:14707172 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14707172 | pubmed:dateCreated | 2004-1-6 | lld:pubmed |
| pubmed-article:14707172 | pubmed:abstractText | As present antibiotics therapy becomes increasingly ineffectual, new technologies are required to identify and develop novel classes of antibacterial agents. An attractive alternative to the classical target-based approach is the use of promoter-inducible reporter assays for high-throughput screening. The wide usage of these assays is, however, limited by the small number of specifically responding promoters that are known at present. This work describes a novel approach for identifying genetic regulators that are suitable for the design of pathway-specific assays. The basis for the proposed strategy is a large set of antibiotics-triggered expression profiles ("Reference Compendium"). Pattern recognition algorithms applied to the expression data pinpoint the relevant transcription-factor-binding sites in whole-genome sequences. Using this technique, we constructed a fatty-acid-pathway-specific reporter assay that is based on a novel stress-inducible promoter. In a proof-of-principle experiment, this assay was shown to enable screening for new small-molecule inhibitors of bacterial growth. | lld:pubmed |
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| pubmed-article:14707172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14707172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14707172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14707172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14707172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14707172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14707172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14707172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14707172 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14707172 | pubmed:issn | 1088-9051 | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:MackoLudwigL | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:FischerHans... | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:FreibergChris... | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:ZiegelbauerKa... | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:BrunnerNina... | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:WielandBerndB | lld:pubmed |
| pubmed-article:14707172 | pubmed:author | pubmed-author:PaquetteJesse... | lld:pubmed |
| pubmed-article:14707172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14707172 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:14707172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14707172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14707172 | pubmed:pagination | 90-8 | lld:pubmed |
| pubmed-article:14707172 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
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| pubmed-article:14707172 | pubmed:meshHeading | pubmed-meshheading:14707172... | lld:pubmed |
| pubmed-article:14707172 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14707172 | pubmed:articleTitle | Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery. | lld:pubmed |
