| pubmed-article:14703694 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14703694 | lifeskim:mentions | umls-concept:C1539715 | lld:lifeskim |
| pubmed-article:14703694 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:14703694 | lifeskim:mentions | umls-concept:C0035147 | lld:lifeskim |
| pubmed-article:14703694 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:14703694 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:14703694 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14703694 | pubmed:dateCreated | 2004-1-5 | lld:pubmed |
| pubmed-article:14703694 | pubmed:abstractText | The eight-twenty-one (ETO) homologues, represented by ETO, myeloid transforming gene-related protein 1 (MTGR1) and myeloid transforming gene chromosome 16 (MTG16), are nuclear repressor proteins. ETO is part of the fusion protein acute myeloid leukaemia (AML)1-ETO, resulting from the translocation (8;21). Similarly, MTG16 is disrupted to become part of AML1/MTG16 in t(16;21). The aberrant expression of these chimeras could affect interplay between ETO homologues and contribute to the leukaemogenic process. We investigated possible interactions between the ETO homologues. Ectopic co-expression in COS-cells resulted in heterodimerisation of the various ETO homologues suggesting that they may co-operate. Similarly, the chimeric oncoprotein AML1-ETO interacted with both MTGR1 and MTG16. However, results from cell lines endogenously expressing more than one ETO homologue did not demonstrate co-precipitation. Results from IP-Western and size determination by gel filtration of deletion mutants expressed in COS-cells, indicated an important role of the HHR domain for oligomerisation. A role was also suggested for the Nervy domain in the homologue interactions. Our results suggest that ETO homologues can interact with each other as well as with AML1-ETO, although it is unclear as to what extent these interactions occur in vivo. | lld:pubmed |
| pubmed-article:14703694 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14703694 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14703694 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14703694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14703694 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14703694 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14703694 | pubmed:issn | 0902-4441 | lld:pubmed |
| pubmed-article:14703694 | pubmed:author | pubmed-author:OlssonIngeI | lld:pubmed |
| pubmed-article:14703694 | pubmed:author | pubmed-author:PerssonAnn-Ma... | lld:pubmed |
| pubmed-article:14703694 | pubmed:author | pubmed-author:LindbergSofia... | lld:pubmed |
| pubmed-article:14703694 | pubmed:author | pubmed-author:OlssonAndréA | lld:pubmed |
| pubmed-article:14703694 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14703694 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:14703694 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14703694 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14703694 | pubmed:pagination | 439-47 | lld:pubmed |
| pubmed-article:14703694 | pubmed:dateRevised | 2007-5-9 | lld:pubmed |
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| pubmed-article:14703694 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14703694 | pubmed:articleTitle | Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. | lld:pubmed |
| pubmed-article:14703694 | pubmed:affiliation | Department of Hematology, C14, BMC, S-221 84 Lund, Sweden. sofia.rondin_lindberg@hematologi.lu.se | lld:pubmed |
| pubmed-article:14703694 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14703694 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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