| pubmed-article:14700633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14700633 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:14700633 | lifeskim:mentions | umls-concept:C0439542 | lld:lifeskim |
| pubmed-article:14700633 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:14700633 | lifeskim:mentions | umls-concept:C0063469 | lld:lifeskim |
| pubmed-article:14700633 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:14700633 | pubmed:dateCreated | 2003-12-31 | lld:pubmed |
| pubmed-article:14700633 | pubmed:abstractText | Gastropod mollusks have been used for over 2500 years to produce the "Tyrian purple" dye made famous by the Phoenicians. This dye is constituted of mixed bromine-substituted indigo and indirubin isomers. Among these, the new natural product 6-bromoindirubin and its synthetic, cell-permeable derivative, 6-bromoindirubin-3'-oxime (BIO), display remarkable selective inhibition of glycogen synthase kinase-3 (GSK-3). Cocrystal structure of GSK-3beta/BIO and CDK5/p25/indirubin-3'-oxime were resolved, providing a detailed view of indirubins' interactions within the ATP binding pocket of these kinases. BIO but not 1-methyl-BIO, its kinase inactive analog, also inhibited the phosphorylation on Tyr276/216, a GSK-3alpha/beta activation site. BIO but not 1-methyl-BIO reduced beta-catenin phosphorylation on a GSK-3-specific site in cellular models. BIO but not 1-methyl-BIO closely mimicked Wnt signaling in Xenopus embryos. 6-bromoindirubins thus provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3. | lld:pubmed |
| pubmed-article:14700633 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14700633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14700633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14700633 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14700633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14700633 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14700633 | pubmed:issn | 1074-5521 | lld:pubmed |
| pubmed-article:14700633 | pubmed:author | pubmed-author:DajaniRanaR | lld:pubmed |
| pubmed-article:14700633 | pubmed:author | pubmed-author:PearlLaurence... | lld:pubmed |
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| pubmed-article:14700633 | pubmed:author | pubmed-author:MagiatisProko... | lld:pubmed |
| pubmed-article:14700633 | pubmed:author | pubmed-author:MeijerLaurent... | lld:pubmed |
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| pubmed-article:14700633 | pubmed:author | pubmed-author:BrivanlouAliA | lld:pubmed |
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| pubmed-article:14700633 | pubmed:author | pubmed-author:TarriconeCata... | lld:pubmed |
| pubmed-article:14700633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14700633 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:14700633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14700633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14700633 | pubmed:pagination | 1255-66 | lld:pubmed |
| pubmed-article:14700633 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14700633 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14700633 | pubmed:articleTitle | GSK-3-selective inhibitors derived from Tyrian purple indirubins. | lld:pubmed |
| pubmed-article:14700633 | pubmed:affiliation | CNRS, Cell Cycle Group, Station Biologique, BP 74, 29682 Roscoff cedex, Bretagne, France. meijer@sb-roscoff.fr | lld:pubmed |
| pubmed-article:14700633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14700633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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