| pubmed-article:14697212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C1421482 | lld:lifeskim |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C1826709 | lld:lifeskim |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C1155950 | lld:lifeskim |
| pubmed-article:14697212 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14697212 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14697212 | pubmed:dateCreated | 2003-12-30 | lld:pubmed |
| pubmed-article:14697212 | pubmed:abstractText | WASP family proteins are involved in cortical actin cytoskeleton reorganization. Neural Wiskott-Aldrich syndrome protein (N-WASP), a ubiquitously expressed WASP homologous protein, directly binds with Cdc42, activating Arp2/3 complex. In this study, we show that N-WASP-dependent microspike formation is inhibited by formin binding protein 11 (FBP11). Endogenous FBP11 localizes with nuclear-speckles, and co-localization of N-WASP and FBP11 was observed when they were co-expressed. Epidermal growth factor (EGF) induced actin-microspike formation in COS7 cells. However, transient expression of FBP11 suppressed N-WASP-dependent actin-microspike formation by trapping N-WASP in the nucleus. These results indicate that FBP11 regulates localization of N-WASP, thus negatively regulating the function of N-WASP in the cytoplasm. | lld:pubmed |
| pubmed-article:14697212 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14697212 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14697212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14697212 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14697212 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:14697212 | pubmed:author | pubmed-author:TakenawaTadao... | lld:pubmed |
| pubmed-article:14697212 | pubmed:author | pubmed-author:MizutaniKiyoh... | lld:pubmed |
| pubmed-article:14697212 | pubmed:author | pubmed-author:SuetsuguShiro... | lld:pubmed |
| pubmed-article:14697212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14697212 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:14697212 | pubmed:volume | 313 | lld:pubmed |
| pubmed-article:14697212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14697212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14697212 | pubmed:pagination | 468-74 | lld:pubmed |
| pubmed-article:14697212 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14697212 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14697212 | pubmed:articleTitle | FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. | lld:pubmed |
| pubmed-article:14697212 | pubmed:affiliation | Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan. | lld:pubmed |
| pubmed-article:14697212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14697212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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