| pubmed-article:1469719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C0004651 | lld:lifeskim |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C1136102 | lld:lifeskim |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:1469719 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:1469719 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1469719 | pubmed:dateCreated | 1993-1-25 | lld:pubmed |
| pubmed-article:1469719 | pubmed:abstractText | RNA ligands with high affinity for the bacteriophage R17 coat protein were isolated from a pool of random RNA molecules using SELEX. Of the 38 ligands isolated, 36 were found to contain a hairpin very similar to the naturally occurring coat protein binding site in the R17 genome. The common features of these 36 sequences provide a consensus binding site and predict components of a hairpin that promote favorable interaction with the coat protein. These include a tetraloop of primary sequence AUCA and a variable-length stem with a bulged adenosine residue at a specific stem position. The predicted consensus agrees well with the highest-affinity RNA binding site of the R17 coat protein, identified through classical but laborious techniques. These results demonstrate the value of SELEX as a tool for isolating high affinity RNA ligands to a specific target protein, and the further value of those ligands to point the researcher toward natural sequences for that target protein. | lld:pubmed |
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| pubmed-article:1469719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1469719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469719 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1469719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1469719 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1469719 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:1469719 | pubmed:author | pubmed-author:SchneiderDD | lld:pubmed |
| pubmed-article:1469719 | pubmed:author | pubmed-author:GoldLL | lld:pubmed |
| pubmed-article:1469719 | pubmed:author | pubmed-author:TuerkCC | lld:pubmed |
| pubmed-article:1469719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1469719 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1469719 | pubmed:volume | 228 | lld:pubmed |
| pubmed-article:1469719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1469719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1469719 | pubmed:pagination | 862-9 | lld:pubmed |
| pubmed-article:1469719 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1469719 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1469719 | pubmed:articleTitle | Selection of high affinity RNA ligands to the bacteriophage R17 coat protein. | lld:pubmed |
| pubmed-article:1469719 | pubmed:affiliation | University of Colorado, Boulder 80309-0347. | lld:pubmed |
| pubmed-article:1469719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1469719 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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