| pubmed-article:1469507 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C0227349 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C1514391 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1469507 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1469507 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1469507 | pubmed:dateCreated | 1993-1-27 | lld:pubmed |
| pubmed-article:1469507 | pubmed:abstractText | L-CAM is a cell adhesion molecule which is expressed at the intercellular borders of most epithelial cells. L-CAM has been demonstrated to act as an invasion suppressor in carcinoma cell lines. In order to determine whether or not L-CAM expression might distinguish between invasive and non-invasive or metastatic and non-metastatic colon neoplasms, we studied L-CAM expression in normal colon mucosa, colon adenomas with various degrees of dysplasia, and colon carcinomas by immunohistochemistry, using the 6F9 monoclonal anti-L-CAM antibody. Normal mucosa showed evenly distributed distinct L-CAM immunoreactivity along intercellular borders. In adenomas and carcinomas, a similar though weaker expression was observed. This pattern showed a tendency to decrease in parallel with decreasing differentiation. However, no correlation was found with Dukes stage or area within the tumour. In some carcinomas, L-CAM was expressed at the luminal surface of the cells. In others, L-CAM expression was not found. These results suggest that L-CAM expression is disregulated or lost as an early event in the development of colon neoplasia and indicate that L-CAM expression does not correlate with invasive or metastatic potential. | lld:pubmed |
| pubmed-article:1469507 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1469507 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469507 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1469507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1469507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469507 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1469507 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1469507 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:BosmanF TFT | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:DinjensW NWN | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:ArendsJ WJW | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:ten KateJJ | lld:pubmed |
| pubmed-article:1469507 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:1469507 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1469507 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:1469507 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1469507 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1469507 | pubmed:pagination | 287-91 | lld:pubmed |
| pubmed-article:1469507 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1469507 | pubmed:meshHeading | pubmed-meshheading:1469507-... | lld:pubmed |
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| pubmed-article:1469507 | pubmed:meshHeading | pubmed-meshheading:1469507-... | lld:pubmed |
| pubmed-article:1469507 | pubmed:meshHeading | pubmed-meshheading:1469507-... | lld:pubmed |
| pubmed-article:1469507 | pubmed:meshHeading | pubmed-meshheading:1469507-... | lld:pubmed |
| pubmed-article:1469507 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1469507 | pubmed:articleTitle | L-CAM expression in normal, premalignant, and malignant colon mucosa. | lld:pubmed |
| pubmed-article:1469507 | pubmed:affiliation | Department of Pathology, University of Limburg, Maastricht, The Netherlands. | lld:pubmed |
| pubmed-article:1469507 | pubmed:publicationType | Journal Article | lld:pubmed |
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