| pubmed-article:14694079 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C0684063 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C0019648 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1425774 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1706229 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1706204 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1555721 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C1709461 | lld:lifeskim |
| pubmed-article:14694079 | lifeskim:mentions | umls-concept:C0008781 | lld:lifeskim |
| pubmed-article:14694079 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14694079 | pubmed:dateCreated | 2004-3-9 | lld:pubmed |
| pubmed-article:14694079 | pubmed:abstractText | The accumulation of divergent histone H4 amino acid sequences within and between ciliate lineages challenges traditional views of the evolution of this essential eukaryotic protein. We analyzed histone H4 sequences from 13 species of ciliates and compared these data with sequences from well-sampled eukaryotic clades. Ciliate histone H4s differ from one another at as many as 46% of their amino acids, in contrast with the highly conserved character of this protein in most other eukaryotes. Equally striking, we find paralogs of histone H4 within ciliate genomes that differ by up to 25% of their amino acids, whereas paralogs in other eukaryotes share identical or nearly identical amino acid sequences. Moreover, the most divergent H4 proteins within ciliates are found in the lineages with highly processed macronuclear genomes. Our analyses demonstrate that the dual nature of ciliate genomes-the presence of a "germline" micronucleus and a "somatic" macronucleus within each cell-allowed the dramatic variation in ciliate histone genes by altering functional constraints or enabling adaptive evolution of the histone H4 protein, or both. | lld:pubmed |
| pubmed-article:14694079 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14694079 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14694079 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14694079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14694079 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14694079 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14694079 | pubmed:issn | 0737-4038 | lld:pubmed |
| pubmed-article:14694079 | pubmed:author | pubmed-author:MuseSpencer... | lld:pubmed |
| pubmed-article:14694079 | pubmed:author | pubmed-author:KatzLaura ALA | lld:pubmed |
| pubmed-article:14694079 | pubmed:author | pubmed-author:Lasek-Nesselq... | lld:pubmed |
| pubmed-article:14694079 | pubmed:author | pubmed-author:BornsteinJaco... | lld:pubmed |
| pubmed-article:14694079 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14694079 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:14694079 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14694079 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14694079 | pubmed:pagination | 555-62 | lld:pubmed |
| pubmed-article:14694079 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:meshHeading | pubmed-meshheading:14694079... | lld:pubmed |
| pubmed-article:14694079 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14694079 | pubmed:articleTitle | Dramatic diversity of ciliate histone H4 genes revealed by comparisons of patterns of substitutions and paralog divergences among eukaryotes. | lld:pubmed |
| pubmed-article:14694079 | pubmed:affiliation | Department of Biological Sciences, Smith College, Northampton, Massachusetts, USA. lkatz@smith.edu | lld:pubmed |
| pubmed-article:14694079 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14694079 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:14694079 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14694079 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14694079 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14694079 | lld:pubmed |
