| pubmed-article:1469122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C1334879 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0040426 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0026973 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0034963 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:1469122 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1469122 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1469122 | pubmed:dateCreated | 1993-1-27 | lld:pubmed |
| pubmed-article:1469122 | pubmed:abstractText | Nerve regeneration was examined in rat molars that were briefly extracted and then replanted in the socket for 1-90 days. Immunocytochemistry was used to evaluate neural and nonneural immunoreactivity (IR) for low affinity nerve growth factor receptor (p75-NGFR) and for laminin and calcitonin gene-related peptide (CGRP). Three different types of pulpal response to replantation were found. Type I: Some replanted teeth had mild injury and still contained coronal odontoblasts and associated fibroblasts that retained p75-NGFR-IR; they continued regular dentin formation and had excellent reinnervation. Type II: Teeth with intermediate injury lost most or all of the coronal pulp tissue, but they regenerated odontoblast-like cells that formed irregular dentin, they had numerous dispersed p75-NGFR-IR fibroblasts in crown pulp during early regeneration, and they had excellent reinnervation. Type III: Severely injured teeth lost their original pulp; they filled with dense connective tissue and bone and had poor reinnervation. After Type I or II injury the Schwann cells around degenerating myelinated and unmyelinated axons had increased expression of p75-NGFR by 1-3 days. By 7-10 days those Schwann cells had formed hollow tubes (bands of Bungner) along the degenerating axon tracks. They maintained their increased p75-NGFR-IR during and after regeneration of unmyelinated axons, whereas Schwann cells involved in remyelination lost p75-NGFR-IR at that stage. The number of CGRP-IR axons in the regenerating pulp increased from 7 to 90 days. Laminin-IR increased in all replanted teeth at 3-10 days and only returned to normal patterns in teeth with Type I or Type II response at 20-90 days. The special p75-NGFR-IR of pulpal fibroblasts of adult rat molars did not usually persist in regenerated, reinnervated pulp. The extensive depletion of fibroblast p75-NGFR-IR and the continuing enhanced p75-NGFR-IR in unmyelinated nerve fibers at 90 days show that altered growth factor conditions characterize regenerated pulp of replanted teeth. | lld:pubmed |
| pubmed-article:1469122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1469122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1469122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1469122 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1469122 | pubmed:issn | 0021-9967 | lld:pubmed |
| pubmed-article:1469122 | pubmed:author | pubmed-author:ByersM RMR | lld:pubmed |
| pubmed-article:1469122 | pubmed:author | pubmed-author:KvinnslandII | lld:pubmed |
| pubmed-article:1469122 | pubmed:author | pubmed-author:BothwellMM | lld:pubmed |
| pubmed-article:1469122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1469122 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1469122 | pubmed:volume | 326 | lld:pubmed |
| pubmed-article:1469122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1469122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1469122 | pubmed:pagination | 470-84 | lld:pubmed |
| pubmed-article:1469122 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:meshHeading | pubmed-meshheading:1469122-... | lld:pubmed |
| pubmed-article:1469122 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1469122 | pubmed:articleTitle | Analysis of low affinity nerve growth factor receptor during pulpal healing and regeneration of myelinated and unmyelinated axons in replanted teeth. | lld:pubmed |
| pubmed-article:1469122 | pubmed:affiliation | Department of Anesthesiology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:1469122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1469122 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1469122 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1469122 | lld:pubmed |
