| pubmed-article:14685242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C1427858 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:14685242 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:14685242 | pubmed:issue | 6968 | lld:pubmed |
| pubmed-article:14685242 | pubmed:dateCreated | 2003-12-19 | lld:pubmed |
| pubmed-article:14685242 | pubmed:abstractText | Although human immunodeficiency virus-1 (HIV-1) infects quiescent and proliferating CD4+ lymphocytes, the virus replicates poorly in resting T cells. Factors that block viral replication in these cells might help to prolong the asymptomatic phase of HIV infection; however, the molecular mechanisms that control this process are not fully understood. Here we show that Murr1, a gene product known previously for its involvement in copper regulation, inhibits HIV-1 growth in unstimulated CD4+ T cells. This inhibition was mediated in part through its ability to inhibit basal and cytokine-stimulated nuclear factor (NF)-kappaB activity. Knockdown of Murr1 increased NF-kappaB activity and decreased IkappaB-alpha concentrations by facilitating phospho-IkappaB-alpha degradation by the proteasome. Murr1 was detected in CD4+ T cells, and RNA-mediated interference of Murr1 in primary resting CD4+ lymphocytes increased HIV-1 replication. Through its effects on the proteasome, Murr1 acts as a genetic restriction factor that inhibits HIV-1 replication in lymphocytes, which could contribute to the regulation of asymptomatic HIV infection and the progression of AIDS. | lld:pubmed |
| pubmed-article:14685242 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14685242 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14685242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14685242 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14685242 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:NabelGary JGJ | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:WijmengaCisca... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:KlompLeo W... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:DuckettColin... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:MascolaJohn... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:LouderMark... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:BursteinEzraE | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:GaneshLakshma... | lld:pubmed |
| pubmed-article:14685242 | pubmed:author | pubmed-author:Guha-NiyogiAn... | lld:pubmed |
| pubmed-article:14685242 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14685242 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:14685242 | pubmed:volume | 426 | lld:pubmed |
| pubmed-article:14685242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14685242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14685242 | pubmed:pagination | 853-7 | lld:pubmed |
| pubmed-article:14685242 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:meshHeading | pubmed-meshheading:14685242... | lld:pubmed |
| pubmed-article:14685242 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14685242 | pubmed:articleTitle | The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. | lld:pubmed |
| pubmed-article:14685242 | pubmed:affiliation | Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA. | lld:pubmed |
| pubmed-article:14685242 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14685242 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4790 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:4792 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:4793 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:5970 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:331 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:6500 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:8454 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| entrez-gene:150684 | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14685242 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14685242 | lld:pubmed |
